Calciprotein particles: balancing mineral homeostasis and vascular pathology

AG Kutikhin, L Feenstra, AE Kostyunin… - … , and vascular biology, 2021 - Am Heart Assoc
Hypercalcemia and hyperphosphatemia associate with an elevated risk of cardiovascular
events, yet the pathophysiological basis of this association is unclear. Disturbed mineral …

Carotid artery plaque calcifications: lessons from histopathology to diagnostic imaging

L Saba, V Nardi, R Cau, A Gupta, H Kamel, JS Suri… - Stroke, 2022 - Am Heart Assoc
The role of calcium in atherosclerosis is controversial and the relationship between vascular
calcification and plaque vulnerability is not fully understood. Although calcifications are …

State-of-the-art CT and MR imaging and assessment of atherosclerotic carotid artery disease: standardization of scanning protocols and measurements—a consensus …

L Saba, C Loewe, T Weikert, MC Williams, N Galea… - European …, 2023 - Springer
Abstract The European Society of Cardiovascular Radiology (ESCR) is the European
specialist society of cardiac and vascular imaging. This society's highest priority is the …

Statin effects on vascular calcification: microarchitectural changes in aortic calcium deposits in aged hyperlipidemic mice

JZ Xian, M Lu, F Fong, R Qiao, NR Patel… - … , and vascular biology, 2021 - Am Heart Assoc
Objective: Statins lower cardiovascular event risk, yet, they paradoxically increase coronary
artery calcification, a marker consistently associated with increased cardiovascular risks. As …

Impact analysis of different CT configurations of carotid artery plaque calcifications on cerebrovascular events

L Saba, H Chen, R Cau, GD Rubeis… - American Journal …, 2022 - Am Soc Neuroradiology
BACKGROUND AND PURPOSE: CT is considered the standard reference both for
quantification and characterization of carotid artery calcifications. Our aim was to investigate …

Nanoparticle-based approaches towards the treatment of atherosclerosis

AY Prilepskii, NS Serov, DV Kladko, VV Vinogradov - Pharmaceutics, 2020 - mdpi.com
Atherosclerosis, being an inflammation-associated disease, represents a considerable
healthcare problem. Its origin remains poorly understood, and at the same time, it is …

Linking Metallic Micronutrients and Toxic Xenobiotics to Atherosclerosis and Fatty Liver Disease—Postmortem ICP-MS Analysis of Selected Human Tissues

J Baj, B Kowalska, A Barbachowska, A Forma… - Nutrients, 2023 - mdpi.com
Dyslipidaemia is a disorder of the lipid metabolism, caused mainly by poor eating habits.
The most severe consequence of an inappropriate diet is the development of …

Fully automated construction of three-dimensional finite element simulations from Optical Coherence Tomography

R Straughan, K Kadry, SA Parikh, ER Edelman… - Computers in Biology …, 2023 - Elsevier
Despite recent advances in diagnosis and treatment, atherosclerotic coronary artery
diseases remain a leading cause of death worldwide. Various imaging modalities and …

The role of sclerostin in bone and ectopic calcification

A De Maré, PC D'Haese, A Verhulst - International journal of molecular …, 2020 - mdpi.com
Sclerostin, a 22-kDa glycoprotein that is mainly secreted by the osteocytes, is a soluble
inhibitor of canonical Wnt signaling. Therefore, when present at increased concentrations, it …

CSL112 (apolipoprotein AI [human]) strongly enhances plasma Apoa-I and cholesterol efflux capacity in post-acute myocardial infarction patients: a PK/PD substudy of …

CM Gibson, SHA Kazmi, S Korjian… - Journal of …, 2022 - journals.sagepub.com
Introduction: Cholesterol efflux capacity (CEC) is impaired following acute myocardial
infarction (AMI). CSL112 is an intravenous preparation of human plasma-derived apoA-I …