Emerging roles of RNA methylation in development
MK Wang, CC Gao, YG Yang - Accounts of Chemical Research, 2023 - ACS Publications
Conspectus More than 170 different types of chemical modifications have been identified on
diverse types of RNA, collectively known as the epitranscriptome. Among them, N 6 …
diverse types of RNA, collectively known as the epitranscriptome. Among them, N 6 …
Base-resolution sequencing methods for whole-transcriptome quantification of mRNA modifications
Conspectus RNA molecules are not merely a combination of four bases of A, C, G, and U.
Chemical modifications occur in almost all RNA species and play diverse roles in gene …
Chemical modifications occur in almost all RNA species and play diverse roles in gene …
M7G modification of FTH1 and pri-miR-26a regulates ferroptosis and chemotherapy resistance in osteosarcoma
M He, Y Wang, J Xie, J Pu, Z Shen, A Wang, T Li… - Oncogene, 2024 - nature.com
Doxorubicin and platinum are widely used in the frontline treatment of osteosarcoma, but
resistance to chemotherapy limits its curative effect. Here, we have identified that METTL1 …
resistance to chemotherapy limits its curative effect. Here, we have identified that METTL1 …
[HTML][HTML] Alternative splicing and related RNA binding proteins in human health and disease
Y Tao, Q Zhang, H Wang, X Yang, H Mu - Signal Transduction and …, 2024 - nature.com
Alternative splicing (AS) serves as a pivotal mechanism in transcriptional regulation,
engendering transcript diversity, and modifications in protein structure and functionality …
engendering transcript diversity, and modifications in protein structure and functionality …
[HTML][HTML] Combined signature of N7-methylguanosine regulators with their related genes and the tumor microenvironment: a prognostic and therapeutic biomarker for …
T Li, Z Chen, Z Wang, J Lu, D Chen - Frontiers in Immunology, 2023 - frontiersin.org
Background Identifying predictive markers for breast cancer (BC) prognosis and
immunotherapeutic responses remains challenging. Recent findings indicate that N7 …
immunotherapeutic responses remains challenging. Recent findings indicate that N7 …
Beyond reader proteins: RNA binding proteins and RNA modifications in conversation to regulate gene expression
C Fagre, W Gilbert - Wiley Interdisciplinary Reviews: RNA, 2024 - Wiley Online Library
Post‐transcriptional mRNA modifications play diverse roles in gene expression and RNA
function. In many cases, RNA modifications function by altering how cellular machinery such …
function. In many cases, RNA modifications function by altering how cellular machinery such …
Stress granule and P-body clearance: Seeking coherence in acts of disappearance
JR Buchan - Seminars in Cell & Developmental Biology, 2024 - Elsevier
Stress granules and P-bodies are conserved cytoplasmic biomolecular condensates whose
assembly and composition are well documented, but whose clearance mechanisms remain …
assembly and composition are well documented, but whose clearance mechanisms remain …
Fibroblast-specific knockout of METTL1 attenuates myocardial infarction-induced cardiac fibrosis
L Wang, J Zhou, L Kong, G Ying, J Sha, D Yi, J Zeng… - Life Sciences, 2023 - Elsevier
Cardiac fibrosis, a common pathology in inherited and acquired heart diseases,
necessitates the identification of diagnostic and therapeutic targets. Methyltransferase Like 1 …
necessitates the identification of diagnostic and therapeutic targets. Methyltransferase Like 1 …
IGFBP1a is a nutrient deficient response factor that can inhibit fish reproduction through the hypothalamus-pituitary-ovary axis
W Li, H Li, Q Hu, L Wang, Z Yin, G Hu - Biology of Reproduction, 2024 - academic.oup.com
Reproduction is a high energy consuming process, so long-term malnutrition can
significantly inhibit gonadal development. However, little is known about the molecular …
significantly inhibit gonadal development. However, little is known about the molecular …
[HTML][HTML] The roles and therapeutic implications of messenger RNA internal N 7‐methylguanosine and N 6‐methyladenosine modifications in chemoresistance
Resistance to chemotherapy is responsible for the death of most cancer patients. RNA
modifications are key players in post-transcriptional gene regulation and their …
modifications are key players in post-transcriptional gene regulation and their …