Polymorphism in the apolipoprotein E (APOE) gene is a major genetic risk determinant of
late-onset Alzheimer disease (AD), with the APOE* ε 4 allele conferring an increased risk …

The global epidemic of Alzheimer disease (AD) is worsening, and no approved treatment
can revert or arrest progression of this disease. AD pathology is characterized by the …

Investigations of apolipoprotein E (APOE) gene, the major genetic risk modifier for
Alzheimer's disease (AD), have yielded significant insights into the pathogenic mechanism …

The APOE ε4 allele remains the strongest genetic risk factor for sporadic Alzheimer's
disease and the APOE ε2 allele the strongest genetic protective factor after multiple large …

Increasing evidence suggests that Alzheimer's disease pathogenesis is not restricted to the
neuronal compartment, but includes strong interactions with immunological mechanisms in …

The past two decades of research into the pathogenesis of Alzheimer disease (AD) have
been driven largely by the amyloid hypothesis; the neuroinflammation that is associated with …

The symptoms of Alzheimer disease reflect a loss of neural circuit integrity in the brain, but
neurons do not work in isolation. Emerging evidence suggests that the intricate balance of …

Effective drug delivery in the central nervous system (CNS) needs to have long blood-
circulation half-lives, to pass through the blood–brain barrier (BBB), and subsequently to be …

ApoE on high-density lipoproteins is primarily responsible for lipid transport and cholesterol
homeostasis in the central nervous system (CNS). Normally produced mostly by astrocytes …

Apolipoprotein (apo) E is a multifunctional protein with central roles in lipid metabolism,
neurobiology, and neurodegenerative diseases. It has three major isoforms (apoE2, apoE3 …