The pig as an animal model for human pathologies: A proteomics perspective

A Bassols, C Costa, PD Eckersall… - PROTEOMICS …, 2014 - Wiley Online Library
Traditional biomedical models are easy to manage in experimental facilities and allow fast
and affordable basic genetic studies related to human disorders, but in some cases they do …

The use of pigs in neuroscience: modeling brain disorders

NM Lind, A Moustgaard, J Jelsing, G Vajta… - Neuroscience & …, 2007 - Elsevier
The use of pigs in neuroscience research has increased in the past decade, which has seen
broader recognition of the potential of pigs as an animal for experimental modeling of …

The pig model in brain imaging and neurosurgery

P Sauleau, E Lapouble, D Val-Laillet, CH Malbert - animal, 2009 - cambridge.org
The pig model is increasingly used in the field of neuroscience because of the similarities of
its brain with human. This review presents the peculiarities of the anatomy and functions of …

Genetically modified pig models for neurodegenerative disorders

IE Holm, AKO Alstrup, Y Luo - The Journal of pathology, 2016 - Wiley Online Library
Increasing incidence of neurodegenerative disorders such as Alzheimer's disease and
Parkinson's disease has become one of the most challenging health issues in ageing …

MR-based statistical atlas of the Göttingen minipig brain

H Watanabe, F Andersen, CZ Simonsen, SM Evans… - Neuroimage, 2001 - Elsevier
Thedomestic pig is increasingly being used as an experimental model for brain imaging
studies with positron emission tomography (PET). The recording of radiotracer uptake by …

Validation of a digital video tracking system for recording pig locomotor behaviour

NM Lind, M Vinther, RP Hemmingsen… - Journal of neuroscience …, 2005 - Elsevier
We are introducing a system for automatically tracking pig locomotor behaviour.
Transposing methods for the video-based tracking of rodent behaviour engenders several …

Animal behavioral assessments in current research of Parkinson's disease

T Asakawa, H Fang, K Sugiyama, T Nozaki… - Neuroscience & …, 2016 - Elsevier
Abstract Parkinson's disease (PD), a neurodegenerative disorder, is traditionally classified
as a movement disorder. Patients typically suffer from many motor dysfunctions. Presently …

Toward sophisticated basal ganglia neuromodulation: review on basal ganglia deep brain stimulation

C Da Cunha, SL Boschen, A Gómez-a, EK Ross… - Neuroscience & …, 2015 - Elsevier
This review presents state-of-the-art knowledge about the roles of the basal ganglia (BG) in
action-selection, cognition, and motivation, and how this knowledge has been used to …

Stem cells in the treatment of Parkinson's disease

E Arenas - Brain research bulletin, 2002 - Elsevier
Stem cells have been suggested as candidate therapeutic tools for neurodegenerative
disorders, given their ability to give rise to the appropriate cell types after grafting in vivo. In …

Development and genome sequencing of a laboratory-inbred miniature pig facilitates study of human diabetic disease

L Zhang, Y Huang, M Wang, Y Guo, J Liang, X Yang… - Iscience, 2019 - cell.com
Pig has been proved to be a valuable large animal model used for research on diabetic
disease. However, their translational value is limited given their distinct anatomy and …