Genomes are subject to a number of exogenous or endogenous DNA-damaging agents that
cause DNA double-strand breaks (DSBs). These critical DNA lesions can result in cell death …

Telomerase has been recognized as a relevant factor distinguishing cancer cells from
normal cells. Thus, it has become a very promising target for anticancer therapy. The cell …

The finite proliferative potential of normal human cells leads to replicative cellular
senescence, which is a critical barrier to tumour progression in vivo,,. We show that the …

Telomeres are localized at the end of chromosomes to provide genome stability; however,
the telomere length tends to be shortened with each cell division inducing a progressive …

The telomere-capping complex shelterin protects functional telomeres and prevents the
initiation of unwanted DNA-damage-response pathways. At the end of cellular replicative …

Δ133p53α, a p53 isoform that can inhibit full-length p53, is downregulated at replicative
senescence in a manner independent of mRNA regulation and proteasome-mediated …

Senescence is defined as a stress-induced durable cell cycle arrest. We herein revisit the
origin of two of these stresses, namely mitochondrial metabolic compromise, associated with …

Telomeres protect the ends of chromosomes but shorten following cell division in the
absence of telomerase activity. When telomeres become critically short or damaged, a DNA …

CRISPR/Cas9 technology enables efficient loss-of-function analysis of human genes using
somatic cells. Studies of essential genes, however, require conditional knockout (KO) cells …

Legumes are special group of N‐fixing plants that are an essential component of cropping
system and important source of food and feed for human and animal consumption. Like …