PDX1+ cell budding morphogenesis in a stem cell-derived islet spheroid system
J Zhao, S Liang, HH Cen, Y Li, RK Baker… - Nature …, 2024 - nature.com
Remarkable advances in protocol development have been achieved to manufacture insulin-
secreting islets from human pluripotent stem cells (hPSCs). Distinct from current …
secreting islets from human pluripotent stem cells (hPSCs). Distinct from current …
Deletion of RFX6 impairs iPSC-derived islet organoid development and survival, with no impact on PDX1+/NKX6. 1+ progenitors
N Aldous, AK Elsayed, B Memon, S Ijaz, S Hayat… - Diabetologia, 2024 - Springer
Methods We examined regulatory factor X6 (RFX6) expression during human embryonic
stem cell (hESC) differentiation into pancreatic islets and re-analysed a single-cell RNA-seq …
stem cell (hESC) differentiation into pancreatic islets and re-analysed a single-cell RNA-seq …