Antimicrobial peptides: Application informed by evolution
BP Lazzaro, M Zasloff, J Rolff - Science, 2020 - science.org
BACKGROUND Antimicrobial peptides (AMPs) are small proteins with potent antibacterial,
antiviral, and antifungal activity. AMPs are ubiquitous among multicellular eukaryotes, with …
antiviral, and antifungal activity. AMPs are ubiquitous among multicellular eukaryotes, with …
Gastrointestinal biofilms in health and disease
Microorganisms colonize various ecological niches in the human habitat, as they do in
nature. Predominant forms of multicellular communities called biofilms colonize human …
nature. Predominant forms of multicellular communities called biofilms colonize human …
Identification of antimicrobial peptides from the human gut microbiome using deep learning
The human gut microbiome encodes a large variety of antimicrobial peptides (AMPs), but
the short lengths of AMPs pose a challenge for computational prediction. Here we combined …
the short lengths of AMPs pose a challenge for computational prediction. Here we combined …
Fight them or feed them: how the intestinal mucus layer manages the gut microbiota
BO Schroeder - Gastroenterology report, 2019 - academic.oup.com
The intestinal tract is inhabited by a tremendous number of microorganisms, termed the gut
microbiota. These microorganisms live in a mutualistic relationship with their host and assist …
microbiota. These microorganisms live in a mutualistic relationship with their host and assist …
Alzheimer's disease-associated β-amyloid is rapidly seeded by herpesviridae to protect against brain infection
WA Eimer, DKV Kumar, NKN Shanmugam… - Neuron, 2018 - cell.com
Amyloid-β peptide (Aβ) fibrilization and deposition as β-amyloid are hallmarks of Alzheimer's
disease (AD) pathology. We recently reported Aβ is an innate immune protein that protects …
disease (AD) pathology. We recently reported Aβ is an innate immune protein that protects …
[HTML][HTML] The antimicrobial protection hypothesis of Alzheimer's disease
Objective We explore here a novel model for amyloidogenesis in Alzheimer's disease (AD).
This new perspective on AD amyloidosis seeks to provide a rational framework for …
This new perspective on AD amyloidosis seeks to provide a rational framework for …
Mucus interaction to improve gastrointestinal retention and pharmacokinetics of orally administered nano-drug delivery systems
DA Subramanian, R Langer, G Traverso - Journal of nanobiotechnology, 2022 - Springer
Oral delivery of therapeutics is the preferred route of administration due to ease of
administration which is associated with greater patient medication adherence. One major …
administration which is associated with greater patient medication adherence. One major …
Amyloid-β peptide protects against microbial infection in mouse and worm models of Alzheimer's disease
DKV Kumar, SH Choi, KJ Washicosky… - Science translational …, 2016 - science.org
The amyloid-β peptide (Aβ) is a key protein in Alzheimer's disease (AD) pathology. We
previously reported in vitro evidence suggesting that Aβ is an antimicrobial peptide. We …
previously reported in vitro evidence suggesting that Aβ is an antimicrobial peptide. We …
[HTML][HTML] Mend your fences: the epithelial barrier and its relationship with mucosal immunity in inflammatory bowel disease
E Martini, SM Krug, B Siegmund, MF Neurath… - Cellular and molecular …, 2017 - Elsevier
The intestinal epithelium can be easily disrupted during gut inflammation as seen in
inflammatory bowel disease (IBD), such as ulcerative colitis or Crohn's disease. For a long …
inflammatory bowel disease (IBD), such as ulcerative colitis or Crohn's disease. For a long …
Interdisciplinary‐inspired smart antibacterial materials and their biomedical applications
The discovery of antibiotics has saved millions of lives, but the emergence of antibiotic‐
resistant bacteria has become another problem in modern medicine. To avoid or reduce the …
resistant bacteria has become another problem in modern medicine. To avoid or reduce the …