Escaping programmed cell death is a hallmark of cancer. NF-κB transcription factors are key
regulator of cell survival and aberrant NF-κB signaling has been involved in the …

Induction of cell death and inhibition of cell survival are the main principles of cancer
therapy. Resistance to chemotherapeutic agents is a major problem in oncology, which …

Abstract The Mitogen Activated Protein Kinase (MAPK) signaling plays a critical role in the
outcome and the sensitivity to anticancer therapies. Activated MAPK can transmit …

The therapeutic potential of autophagy for the treatment cancer and other diseases is beset
by paradoxes stemming from the complexity of the interactions between the apoptotic and …

Autophagy is a lysosomal degradation pathway that degrades damaged or superfluous cell
components into basic biomolecules, which are then recycled back into the cytosol. In this …

Chloroquine (CQ) is a 4-aminoquinoline drug used for the treatment of diverse diseases. It
inhibits lysosomal acidification and therefore prevents autophagy by blocking …

Autophagy is the process by which cellular material is delivered to lysosomes for
degradation and recycling. There are three different types of autophagy, but …

Cisplatin-based treatment is the first line chemotherapy for several cancers including
ovarian cancer. The development of cisplatin resistance results in treatment failure, but the …

Purpose Autophagy is a cell survival mechanism that plays a critical role in pancreatic
carcinogenesis. Murine studies have previously demonstrated that treatment with the late …

The tumor microenvironment is a key factor in disease progression, local resistance,
immune-escaping, and metastasis. The rapid proliferation of tumor cells and the aberrant …