Fibrodysplasia ossificans progressiva

FS Kaplan, M Le Merrer, DL Glaser, RJ Pignolo… - Best practice & research …, 2008 - Elsevier
Fibrodysplasia ossificans progressiva (FOP), a rare and disabling genetic condition of
congenital skeletal malformations and progressive heterotopic ossification (HO), is the most …

Regulation of chondrogenesis and chondrocyte differentiation by stress

MJ Zuscik, MJ Hilton, X Zhang, D Chen… - The Journal of …, 2008 - Am Soc Clin Investig
Chondrogenesis and endochondral ossification are the cartilage differentiation processes
that lead to skeletal formation and growth in the developing vertebrate as well as skeletal …

Classic and atypical fibrodysplasia ossificans progressiva (FOP) phenotypes are caused by mutations in the bone morphogenetic protein (BMP) type I receptor …

FS Kaplan, M Xu, P Seemann, JM Connor… - Human …, 2009 - Wiley Online Library
Fibrodysplasia ossificans progressiva (FOP) is an autosomal dominant human disorder of
bone formation that causes developmental skeletal defects and extensive debilitating bone …

Structure of the bone morphogenetic protein receptor ALK2 and implications for fibrodysplasia ossificans progressiva

A Chaikuad, I Alfano, G Kerr, CE Sanvitale… - Journal of Biological …, 2012 - ASBMB
Bone morphogenetic protein (BMP) receptor kinases are tightly regulated to control
development and tissue homeostasis. Mutant receptor kinase domains escape regulation …

Constitutively activated ALK2 and increased SMAD1/5 cooperatively induce bone morphogenetic protein signaling in fibrodysplasia ossificans progressiva

T Fukuda, M Kohda, K Kanomata, J Nojima… - Journal of Biological …, 2009 - ASBMB
Fibrodysplasia ossificans progressiva (FOP) is a rare autosomal dominant disorder
characterized by congenital malformation of the great toes and by progressive heterotopic …

Hematopoietic stem-cell contribution to ectopic skeletogenesis

FS Kaplan, DL Glaser, EM Shore, RJ Pignolo, M Xu… - JBJS, 2007 - journals.lww.com
Background: Fibrodysplasia ossificans progressiva is a rare genetic disorder of ectopic
skeletogenesis associated with dysregulation of bone morphogenetic protein (BMP) …

Skeletal metamorphosis in fibrodysplasia ossificans progressiva (FOP)

FS Kaplan, Q Shen, V Lounev, P Seemann… - Journal of bone and …, 2008 - Springer
Metamorphosis, the transformation of one normal tissue or organ system into another, is a
biological process rarely studied in higher vertebrates or mammals, but exemplified …

A unique case of fibrodysplasia ossificans progressiva with an ACVR1 mutation, G356D, other than the common mutation (R206H)

H Furuya, K Ikezoe, L Wang, Y Ohyagi… - American Journal of …, 2008 - Wiley Online Library
Fibrodysplasia ossificans progressiva (FOP) is a rare autosomal dominant congenital
disease characterized by progressive heterotopic endochondral osteogenesis with great …

Proximal tibial osteochondromas in patients with fibrodysplasia ossificans progressiva

GK Deirmengian, NM Hebela, M O'Connell, DL Glaser… - JBJS, 2008 - journals.lww.com
Background: Fibrodysplasia ossificans progressiva is a rare autosomal dominant disorder
characterized by congenital malformation of the great toes and by progressive heterotopic …

When the nervous system turns skeletal muscles into bones: how to solve the conundrum of neurogenic heterotopic ossification

KA Alexander, HW Tseng, M Salga, F Genêt… - Current osteoporosis …, 2020 - Springer
Abstract Purpose of Review Neurogenic heterotopic ossification (NHO) is the abnormal
formation of extra-skeletal bones in periarticular muscles after damage to the central …