Piperazine is one of the most sought heterocyclics for the development of new drug
candidates. This ring can be traced in a number of well established, commercially available …

The 1, 8‐naphthyridine group of compounds have gained special attention of researchers
on account of their demonstrating a variety of interesting biological activities. A wide range of …

Abstract Serotonin (5‐hydroxytryptophan [5‐HT]) is a biologically active amine expressed in
platelets, in gastrointestinal (GI) cells and, to a lesser extent, in the central nervous system …

Antibiotic resistance can be characterized, in biochemical terms, as an antibiotic's inability to
reach its bacterial target at a concentration that was previously effective. Microbial resistance …

Stress in our daily life severely affects the normal physiology of the biological system.
Dysregulation of hypothalamic–pituitary–adrenal (HPA) axis has been implicated in the …

Abstract 5HT 3 receptors (5HT3Rs) have long been identified as a potential target for
antidepressants. Several studies have reported that antagonism of 5HT3Rs produces …

More effective treatments for major depression are needed. We studied if the selective 5-HT
3 receptor antagonist ondansetron can potentiate the antidepressant potential of the …

Aim: To investigate the antidepressant-like effects of a novel 5-HT 3 receptor antagonist N-
(benzo [d] thiazol-2-yl)-3-methoxyquinoxalin-2-carboxamide (6z) in acute and chronic …

Depression and anxiety are the most debilitating mood disorders with poor therapeutic
recovery rates. In the last decades, 5-HT 3 receptor antagonists have been identified as …

Aims Piperazinic derivatives have therapeutic potential by acting as analgesic,
antidepressant-like, anticonvulsant and antipsychotic in preclinical studies. In order to …