The promise of precision medicine in rheumatology

JM Guthridge, CA Wagner, JA James - Nature medicine, 2022 - nature.com
Systemic autoimmune rheumatic diseases (SARDs) exhibit extensive heterogeneity in
clinical presentation, disease course, and treatment response. Therefore, precision …

SARS‐CoV‐2 infection as a trigger of autoimmune response

MC Sacchi, S Tamiazzo, P Stobbione… - Clinical and …, 2021 - Wiley Online Library
Currently, few evidences have shown the possible involvement of autoimmunity in patients
affected by coronavirus disease 2019 (COVID‐19). In this study, we elucidate whether …

Update on vasculitis: overview and relevant dermatological aspects for the clinical and histopathological diagnosis - Part II,

TCAB Morita, PR Criado, RFJ Criado… - Anais brasileiros de …, 2020 - SciELO Brasil
Vasculitis is a group of several clinical conditions in which the main histopathological finding
is fibrinoid necrosis in the walls of blood vessels. This article assesses the main …

Autoantibodies in COVID‐19 correlate with antiviral humoral responses and distinct immune signatures

P Taeschler, C Cervia, Y Zurbuchen, S Hasler, C Pou… - Allergy, 2022 - Wiley Online Library
Background Several autoimmune features occur during coronavirus disease 2019 (COVID‐
19), with possible implications for disease course, immunity, and autoimmune pathology. In …

The biology, pathogenetic role, clinical implications, and open issues of serum anti-neutrophil cytoplasmic antibodies

G Ramponi, M Folci, M De Santis… - Autoimmunity …, 2021 - Elsevier
Anti-neutrophil cytoplasmic antibodies (ANCA) are a group of autoantibodies, predominantly
IgG, involved in the pathogenesis of several autoimmune disorders, detected either through …

Non-specific orbital inflammation: current understanding and unmet needs

MJ Lee, SR Planck, D Choi, CA Harrington… - Progress in Retinal and …, 2021 - Elsevier
Non-specific orbital inflammation (NSOI) is a noninfectious inflammatory condition of the
orbit. Although it is generally considered the most common diagnosis derived from an orbital …

The Role of Neutrophils in ANCA-Associated Vasculitis: The Pathogenic Role and Diagnostic Utility of Autoantibodies

A Walulik, K Łysak, M Błaszkiewicz, I Górecki… - International Journal of …, 2023 - mdpi.com
Recent years have brought progress in understanding the role of the neutrophil, dispelling
the dogma of homogeneous cells mainly involved in the prime defence against pathogens …

Autoantibodies as biomarker and therapeutic target in systemic sclerosis

H Graßhoff, K Fourlakis, S Comdühr, G Riemekasten - Biomedicines, 2022 - mdpi.com
Systemic sclerosis (SSc) is a rare connective tissue disorder characterized by immune
dysregulation evoking the pathophysiological triad of inflammation, fibrosis and …

Autoimmune complications of COVID-19 and potential consequences for long-lasting disease syndromes

J Amiral, J Seghatchian - Transfusion and Apheresis Science, 2023 - Elsevier
The latest WHO report determined the increasing diversity within the CoV-2 omicron and its
descendent lineages. Some heavily mutated offshoots of BA. 5 and BA. 2, such as BA. 4.6 …

Antiphospholipid antibodies and lipids in hematological malignancies

SG Barreno-Rocha, S Guzmán-Silahua… - International Journal of …, 2022 - mdpi.com
One of the main groups of lipids is phospholipids, which are mainly involved in forming cell
membranes. Neoplastic processes such as cell replication have increased lipid synthesis …