Mitochondria with structural and functional integrity are essential for maintaining
mitochondrial function and cardiac homeostasis. It is involved in the pathogenesis of many …

Peroxisome proliferator-activated receptor gamma coactivator-1 (PGC-1) family (PGC-1s),
consisting of three members encompassing PGC-1α, PGC-1β, and PGC-1-related …

Metabolic adaption is crucial for the heart to sustain its contractile activity under various
physiological and pathological conditions. At the molecular level, the changes in energy …

SMYD1, a striated muscle-specific lysine methyltransferase, was originally shown to play a
key role in embryonic cardiac development but more recently we demonstrated that loss of …

Cardiovascular diseases (CVDs) are the leading cause of morbidity and mortality worldwide.
Epidemiological studies indicate that pre-menopausal women are more protected against …

Ischemic heart disease affects millions of people around the world. Current treatment
options, including coronary artery bypass grafting, do not result in full functional recovery …

Aims PERM1 is a striated muscle-specific regulator of mitochondrial bioenergetics. We
previously demonstrated that PERM1 is downregulated in the failing heart and that PERM1 …

Introduction Heart failure is a complex clinical syndrome resulting from the unsuccessful
compensation of symptoms of myocardial damage. Mitochondrial dysfunction is a process …

The transcriptional regulatory machinery in mitochondrial bioenergetics is complex and is
still not completely understood. We previously demonstrated that the histone …

Background Pathological cardiac hypertrophy is a major risk factor for cardiovascular
diseases, including heart failure. However, limited pharmacological therapies are available …