Metabolic reprogramming in cancer is not only a biological hallmark but also reveals
treatment vulnerabilities. Numerous metabolic molecules have shown promise as treatment …

Isocitrate dehydrogenase (IDH) mutant gliomas are the most common adult, malignant
primary brain tumors diagnosed in patients younger than 50, constituting an important cause …

MYC-driven medulloblastoma (MB) is an aggressive pediatric brain tumor characterized by
therapy resistance and disease recurrence. Here, we integrated data from unbiased genetic …

Nucleotides are the foundational elements of life. Proliferative cells acquire nutrients for
energy production and the synthesis of macromolecules, including proteins, lipids, and …

Tumors are comprised of a multitude of cell types spanning different microenvironments.
Mass spectrometry imaging (MSI) has the potential to identify metabolic patterns within the …

Diffuse midline glioma (DMG) is a uniformly fatal pediatric cancer driven by oncohistones
that do not readily lend themselves to drug development. To identify druggable targets for …

Nucleotides are substrates for multiple anabolic pathways, most notably DNA and RNA
synthesis. Since nucleotide synthesis inhibitors began to be used for cancer therapy in the …

O-linked β-N-acetyl glucosamine (O-GlcNAc) is at the crossroads of cellular metabolism,
including glucose and glutamine; its dysregulation leads to molecular and pathological …

Aims Nucleotide de novo synthesis is essential to cell growth and survival, and its
dysregulation leads to cancers and drug resistance. However, how this pathway is …

Abstract Purpose of Review Molecular profiling enables the evaluation of genetic alterations
for the diagnosis and classification of gliomas and the selection of appropriate therapies …