ATM, ATR, and DNA-PK: The Trinity at the Heart of the DNA Damage Response
AN Blackford, SP Jackson - Molecular cell, 2017 - cell.com
In vertebrate cells, the DNA damage response is controlled by three related kinases: ATM,
ATR, and DNA-PK. It has been 20 years since the cloning of ATR, the last of the three to be …
ATR, and DNA-PK. It has been 20 years since the cloning of ATR, the last of the three to be …
The DNA-dependent protein kinase
GCM Smith, SP Jackson - Genes & development, 1999 - genesdev.cshlp.org
The DNA-dependent protein kinase (DNA–PK) is a nuclear serine/threonine protein kinase
that is activated upon association with DNA. Biochemical and genetic data have revealed …
that is activated upon association with DNA. Biochemical and genetic data have revealed …
A single ataxia telangiectasia gene with a product similar to PI-3 kinase
K Savitsky, A Bar-Shira, S Gilad, G Rotman, Y Ziv… - Science, 1995 - science.org
A gene, ATM, that is mutated in the autosomal recessive disorder ataxia telangiectasia (AT)
was identified by positional cloning on chromosome 11q22-23. AT is characterized by …
was identified by positional cloning on chromosome 11q22-23. AT is characterized by …
Regulation of RAD53 by the ATM-Like Kinases MEC1 and TEL1 in Yeast Cell Cycle Checkpoint Pathways
Mutants of the Saccharomyces cerevisiae ataxia telangiectasia mutated (ATM) homolog
MEC1/SAD3/ESR1 were identified that could live only if the RAD53/SAD1 checkpoint kinase …
MEC1/SAD3/ESR1 were identified that could live only if the RAD53/SAD1 checkpoint kinase …
DNA-dependent protein kinase catalytic subunit: a relative of phosphatidylinositol 3-kinase and the ataxia telangiectasia gene product
KO Hartley, D Gell, GCM Smith, H Zhang, N Divecha… - Cell, 1995 - cell.com
DNA-dependent protein kinase (DNA-PK), which is involved in DNA double-stranded break
repair and V (D) J recombination, comprises a DNA-targeting component called Ku and an …
repair and V (D) J recombination, comprises a DNA-targeting component called Ku and an …
[HTML][HTML] Overexpression of a kinase‐inactive ATR protein causes sensitivity to DNA‐damaging agents and defects in cell cycle checkpoints
WA Cliby, CJ Roberts, KA Cimprich, CM Stringer… - The EMBO …, 1998 - embopress.org
ATR, a phosphatidylinositol kinase‐related protein homologous to ataxia telangiectasia
mutated (ATM), is important for the survival of human cells following many forms of DNA …
mutated (ATM), is important for the survival of human cells following many forms of DNA …
The complete sequence of the coding region of the ATM gene reveals similarity to cell cycle regulators in different species
K Savitsky, S Sfez, DA Tagle, Y Ziv… - Human molecular …, 1995 - academic.oup.com
Ataxia-telangiectasia (AT) is an autosomal recessive disorder involving cerebellar
degeneration, immunodeficiency, radiation sensitivity, and cancer predisposition. AT …
degeneration, immunodeficiency, radiation sensitivity, and cancer predisposition. AT …
Requirement for the kinase activity of human DNA-dependent protein kinase catalytic subunit in DNA strand break rejoining
A Kurimasa, S Kumano, NV Boubnov… - … and cellular biology, 1999 - Taylor & Francis
The catalytic subunit of DNA-dependent protein kinase (DNA-PKcs) is an enormous, 470-
kDa protein serine/threonine kinase that has homology with members of the …
kDa protein serine/threonine kinase that has homology with members of the …
The Schizosaccharomyces pombe rad3 checkpoint gene.
NJ Bentley, DA Holtzman, G Flaggs, KS Keegan… - The EMBO …, 1996 - embopress.org
The rad3 gene of Schizosaccharomyces pombe is required for checkpoint pathways that
respond to DNA damage and replication blocks. We report the complete rad3 gene …
respond to DNA damage and replication blocks. We report the complete rad3 gene …
rad-Dependent Response of the chk1-Encoded Protein Kinase at the DNA Damage Checkpoint
NC Walworth, R Bernards - Science, 1996 - science.org
Exposure of eukaryotic cells to agents that generate DNA damage results in transient arrest
of progression through the cell cycle. In fission yeast, the DNA damage checkpoint …
of progression through the cell cycle. In fission yeast, the DNA damage checkpoint …