Clinically ineffective reperfusion after endovascular therapy in acute ischemic stroke

X Nie, X Leng, Z Miao, M Fisher, L Liu - Stroke, 2023 - Am Heart Assoc
Endovascular treatment is a highly effective therapy for acute ischemic stroke due to large
vessel occlusion. However, in clinical practice, nearly half of the patients do not have …

No-reflow phenomenon in stroke patients: a systematic literature review and meta-analysis of clinical data

A Mujanovic, F Ng, TR Meinel… - … Journal of Stroke, 2024 - journals.sagepub.com
Background: The no-reflow phenomenon refers to the absence of microvascular reperfusion
despite macrovascular reperfusion. Aim: The aim of this analysis was to summarize the …

Effect of intra-arterial alteplase vs placebo following successful thrombectomy on functional outcomes in patients with large vessel occlusion acute ischemic stroke: the …

A Renú, M Millán, L San Roman, J Blasco… - Jama, 2022 - jamanetwork.com
Importance It is estimated that only 27% of patients with acute ischemic stroke and large
vessel occlusion who undergo successful reperfusion after mechanical thrombectomy are …

Prevalence and significance of impaired microvascular tissue reperfusion despite macrovascular angiographic reperfusion (no-reflow)

FC Ng, L Churilov, N Yassi, TJ Kleinig, V Thijs, T Wu… - Neurology, 2022 - AAN Enterprises
Background and Objectives The relevance of impaired microvascular tissue-level
reperfusion despite complete upstream macrovascular angiographic reperfusion (no-reflow) …

Microvascular dysfunction in blood-brain barrier disruption and hypoperfusion within the infarct posttreatment are associated with cerebral edema

FC Ng, L Churilov, N Yassi, TJ Kleinig, V Thijs, TY Wu… - Stroke, 2022 - Am Heart Assoc
Background: Factors contributing to cerebral edema in the post-hyperacute period of
ischemic stroke (first 24–72 hours) are poorly understood. Blood-brain barrier (BBB) …

[HTML][HTML] Risk factors, pathophysiologic mechanisms, and potential treatment strategies of futile recanalization after endovascular therapy in acute ischemic stroke

G Deng, Y Chu, J Xiao, K Shang, LQ Zhou… - Aging and …, 2023 - ncbi.nlm.nih.gov
Endovascular therapy is the first-line treatment for acute ischemic stroke. However, studies
have shown that, even with the timely opening of occluded blood vessels, nearly half of all …

No-reflow post-recanalization in acute ischemic stroke: mechanisms, measurements, and molecular markers

CP Sperring, WM Savage, MG Argenziano, VP Leifer… - Stroke, 2023 - Am Heart Assoc
Acute ischemic stroke remains the primary cause of disability worldwide. For patients with
large vessel occlusions, intravenous thrombolysis followed by mechanical thrombectomy …

Adjunct thrombolysis enhances brain reperfusion following successful thrombectomy

C Laredo, A Rodríguez, L Oleaga… - Annals of …, 2022 - Wiley Online Library
Objective This study was undertaken to investigate whether adjunct alteplase improves
brain reperfusion following successful thrombectomy. Methods This single‐center …

“No-reflow” phenomenon in acute ischemic stroke

Y Zhang, M Jiang, Y Gao, W Zhao… - Journal of Cerebral …, 2024 - journals.sagepub.com
Acute ischemic stroke (AIS) afflicts millions of individuals worldwide. Despite the
advancements in thrombolysis and thrombectomy facilitating proximal large artery …

Association of serum albumin to globulin ratio with outcomes in acute ischemic stroke

A Wang, Y Zhang, G Xia, X Tian, Y Zuo… - CNS Neuroscience …, 2023 - Wiley Online Library
Background Serum albumin to globulin ratio (A/G) has been widely used as a representative
biomarker for assessing inflammation and nutrition status. However, in patients with acute …