Pyrvinium for the Treatment of Cancer

E Lee, L Lee, C Thorne, E Tahinci… - US Patent App. 12 …, 2009 - Google Patents
The present invention concerns a pyrvinium compound or an analog thereof for the
treatment of cancers. This compound inhibits Wnt activity in the cells of cancers such as …

Methods, compositions and apparatuses for facilitating regeneration

L Gruber - US Patent 9,161,810, 2015 - Google Patents
Apparatuses, compositions and methods for removing cells which interfere with regenerative
processes. The apparatuses, compositions and methods selectively kill partially func tional …

Pegylated drug-linkers for improved ligand-drug conjugate pharmacokinetics

R Lyon, P Burke, J Hunter - US Patent 11,103,593, 2021 - Google Patents
2021-04-22 First worldwide family litigation filed litigation Critical https://patents. darts-ip.
com/? family= 52828847&utm_source= google_patent&utm_medium …

Multivalent constructs for therapeutic and diagnostic applications

C Arbogast, P Bussat, H Fan, KE Linder… - US Patent …, 2007 - Google Patents
2005-02-18 Assigned to BRACCO INTERNATIONAL BV reassignment BRACCO
INTERNATIONAL BV ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT FOR …

Anti-age antibodies for treating inflammation and auto-immune disorders

LS Gruber - US Patent 10,584,180, 2020 - Google Patents
(57) ABSTRACT A composition for treating inflammation or auto-immune disorders
comprises (i) an antibody that binds to an AGE-modified protein on a cell, and (ii) an anti …

Selective removal of age-modified cells for treatment of atherosclerosis

L Gruber - US Patent 9,649,376, 2017 - Google Patents
A method of treating atherosclerosis comprises removing AGE-modified cells from a patient.
The AGE-modified cells include erythrocytes, intima cells, endothelial cells, smooth muscle …

Humanized monoclonal advanced glycation end-product antibody

LS Gruber - US Patent 10,919,957, 2021 - Google Patents
6,090,382 A 6,176,842 B1 6,245,318 B1 6,309,355 B1 6,380,165 B1 6,387,373 B1
6,410,598 B1 6,670,136 B2 6,676,963 B1 6,818,215 B2 6,821,274 B2 7,033,574 B1 …

Product and method for treating sarcopenia

LS Gruber - US Patent 10,358,502, 2019 - Google Patents
A method of treating sarcopenia comprises administering to a subject a composition
comprising an anti-AGE antibody. The method may also be used for preventing or delaying …

Method and composition for treating sarcopenia

LS Gruber - US Patent 9,993,535, 2018 - Google Patents
(57) ABSTRACT A method of treating sarcopenia comprises immunizing a subject in need
thereof against AGE-modified proteins or peptides of a cell. Immunizing a subject includes …

Selective removal of cells having accumulated agents

LS Gruber - US Patent 10,960,234, 2021 - Google Patents
6,176,842 B1 6,245,318 B1 6,309,355 B1 6,380,165 B1 6,387,373 B1 6,410,598 B1
6,670,136 B2 6,676,963 B1 6,818,215 B2 6,821,274 B2 7,033,574 B1 7,101,838 B2 …