Pre-eclampsia is a life-threatening disease of pregnancy unique to humans and a leading
cause of maternal and neonatal morbidity and mortality. Women who survive pre-eclampsia …

Preeclampsia accounts for one of the most common documented gestational complications,
with a prevalence of approximately 2 to 15% of all pregnancies. Defined as gestational …

Maternal vascular adaptation to pregnancy is critically important in order to expand the
capacity for blood flow through the uteroplacental unit to meet the needs of the developing …

Hypertensive disorders of pregnancy serve as risk factors for both ischemic and
hemorrhagic strokes in pregnancy. A crosssectional study of≈ 82 000 000 pregnancy …

Preeclampsia (PE), a hypertensive disorder, occurs in 3% to 8% of pregnancies in the
United States and affects over 200,000 women and newborns per year. The United States …

Background Pre‐eclampsia is a pregnancy‐associated condition with complex disease
mechanisms and a risk factor for various long‐term health outcomes for the mother and …

The complement cascade was identified over 100 years ago, yet investigation of its role in
pregnancy remains an area of intense research. Complement inhibitors at the maternal-fetal …

Animal models have been critical in investigating the pathogenesis, mediators, and even
therapeutic options for a number of diseases, including preeclampsia. Preeclampsia is the …

Preeclampsia, a pregnancy-related endothelial disorder, is associated with both
cardiovascular and cerebrovascular complications. Preeclampsia requires the presence of a …

Pregnancy and the puerperium confer an increased risk for ischemic as well as hemorrhagic
stroke, with incidence rates being 3-fold higher as compared with nonpregnant women. A …