TP53 is a critical tumor-suppressor gene that is mutated in more than half of all human
cancers. Mutations in TP53 not only impair its antitumor activity, but also confer mutant p53 …

Optical techniques using developed laser and optical devices have made a profound impact
on modern medicine, with “biomedical optics” becoming an emerging field. Sophisticated …

MicroRNA (miR)‐based therapy shows strong potential; however, structural limitations pose
a challenge in fully exploiting its biomedical functionality. Tetrahedral framework DNA (tFNA) …

The advent of genome editing has transformed the therapeutic landscape for several
debilitating diseases, and the clinical outlook for gene therapeutics has never been more …

Simple Summary Drug resistance remains one of the major problems in cancer therapy and
is responsible for up to 90% of cancer-related deaths. It exists across all types of cancer and …

MicroRNAs (miRNAs) are small non-coding RNAs with a length of about 19–25 nt, which
can regulate various target genes and are thus involved in the regulation of a variety of …

Autism spectrum disorder (ASD) is a prevalent and complex neurodevelopmental disorder
which has strong genetic basis. Despite the rapidly rising incidence of autism, little is known …

Recent advances have begun to clarify the physiological and pathological roles of non-
coding RNAs (ncRNAs) in various diseases, including cancer. Among these, microRNAs …

RNAi therapeutics have been growing. Patisiran and givosiran, two siRNA-based drugs,
were approved by the Food and Drug Administration in 2018 and 2019, respectively …

The rapid expansion of the available genomic data continues to greatly impact biomedical
science and medicine. Fulfilling the clinical potential of genetic discoveries requires the …