The proteins of the BCL-2 family are key regulators of mitochondrial apoptosis, acting as
either promoters or inhibitors of cell death. The functional interplay and balance between the …

Apoptosis is a form of regulated cell death (RCD) that involves proteases of the caspase
family. Pharmacological and genetic strategies that experimentally inhibit or delay apoptosis …

Through their many and varied metabolic functions, mitochondria power life. Paradoxically,
mitochondria also have a central role in apoptotic cell death. Upon induction of …

Twelve regulated cell death programs have been described. We review in detail the basic
biology of nine including death receptor-mediated apoptosis, death receptor-mediated …

Bcl-2-associated X protein (BAX) is a critical executioner of mitochondrial regulated cell
death through its lethal activity of permeabilizing the mitochondrial outer membrane (MOM) …

Deregulation of the BCL-2 family interaction network ensures cancer resistance to apoptosis
and is a major challenge to current treatments. Cancer cells commonly evade apoptosis …

Abstract Gasdermin E (GSDME/DFNA5) cleavage by caspase-3 liberates the GSDME-N
domain, which mediates pyroptosis by forming pores in the plasma membrane. Here we …

Over the past decade, the Nomenclature Committee on Cell Death (NCCD) has formulated
guidelines for the definition and interpretation of cell death from morphological, biochemical …

Neuronal cell death occurs extensively during development and pathology, where it is
especially important because of the limited capacity of adult neurons to proliferate or be …

Bax and Bak are members of the Bcl‐2 family and core regulators of the intrinsic pathway of
apoptosis. Upon apoptotic stimuli, they are activated and oligomerize at the mitochondrial …