Aurora kinase A (AURKA) belongs to the family of serine/threonine kinases, whose
activation is necessary for cell division processes via regulation of mitosis. AURKA shows …

Cancer is characterized by uncontrolled tumour cell proliferation resulting from aberrant
activity of various cell cycle proteins. Therefore, cell cycle regulators are considered …

Although rituximab plus cyclophosphamide, doxorubicin, vincristine, and prednisone (R-
CHOP) is the standard treatment for patients with diffuse large B-cell lymphoma (DLBCL),∼ …

The Aurora kinase family comprises of cell cycle-regulated serine/threonine kinases
important for mitosis. Their activity and protein expression are cell cycle regulated, peaking …

The Aurora kinase family is comprised of three serine/threonine kinases, Aurora‐A, Aurora‐
B, and Aurora‐C. Among these, Aurora‐A and Aurora‐B play central roles in mitosis …

Background Alisertib is an investigational, oral, selective inhibitor of aurora kinase A. We
aimed to investigate the safety and activity of single-agent alisertib in patients with …

Importance Aurora A kinase (AURKA) activation, related in part toAURKAamplification and
variants, is associated with downregulation of estrogen receptor (ER) α expression …

Histologic transformation of follicular lymphoma to an aggressive non-Hodgkin lymphoma is
a critical biologic event with profound implications on the natural history of this otherwise …

PURPOSE The aim of this open-label, first-in-setting, randomized phase III trial was to
evaluate the efficacy of alisertib, an investigational Aurora A kinase inhibitor, in patients with …

Cancer therapies trigger diverse cellular responses, ranging from apoptotic death to
acquisition of persistent therapy-refractory states such as senescence. Tipping the balance …