Therapeutic Strategies Targeting Pancreatic Islet β-Cell Proliferation, Regeneration, and Replacement
Diabetes results from insufficient insulin production by pancreatic islet β-cells or a loss of β-
cells themselves. Restoration of regulated insulin production is a predominant goal of …
cells themselves. Restoration of regulated insulin production is a predominant goal of …
Interferons are key cytokines acting on pancreatic islets in type 1 diabetes
A Coomans de Brachène, MI Alvelos, F Szymczak… - Diabetologia, 2024 - Springer
Aims/hypothesis The proinflammatory cytokines IFN-α, IFN-γ, IL-1β and TNF-α may
contribute to innate and adaptive immune responses during insulitis in type 1 diabetes and …
contribute to innate and adaptive immune responses during insulitis in type 1 diabetes and …
Moving from insulin substitution to the treatment of the underlying autoimmune disease in type 1 diabetes
J Weiskorn, T Danne - Hormone Research in Paediatrics, 2024 - karger.com
Currently a paradigm change occurs in type 1 diabetes from insulin substitution to the
treatment of the underlying autoimmune disease. Teplizumab, a humanized monoclonal anti …
treatment of the underlying autoimmune disease. Teplizumab, a humanized monoclonal anti …
[HTML][HTML] Semaglutide Treatment in Adult-Onset Autoimmune Diabetes: A Case Study With Long-Term Follow-Up and Periodic Evaluation of Beta-Cell Function
A Da Porto, E Varisco, M Antonello, V Casarsa… - Cureus, 2024 - ncbi.nlm.nih.gov
Latent autoimmune diabetes of adults (LADA) is a form of autoimmune diabetes that typically
occurs in adulthood and has intermediate characteristics between type 1 and type 2 …
occurs in adulthood and has intermediate characteristics between type 1 and type 2 …
[PDF][PDF] Interferons are the key cytokines acting on pancreatic islets in type 1 diabetes
AC de Brachène, MI Alvelos, F Szymczak, PL Zimath… - Diabetologia - researchgate.net
The pro-inflammatory cytokines IFNα, IFNγ, IL-1β and TNFα may contribute to innate and
adaptive immune responses during islet inflammation (insulitis) in type 1 diabetes (T1D). We …
adaptive immune responses during islet inflammation (insulitis) in type 1 diabetes (T1D). We …