Artificial intelligence in epilepsy—applications and pathways to the clinic

A Lucas, A Revell, KA Davis - Nature Reviews Neurology, 2024 - nature.com
Artificial intelligence (AI) is rapidly transforming health care, and its applications in epilepsy
have increased exponentially over the past decade. Integration of AI into epilepsy …

Clinical utility of sleep recordings during presurgical epilepsy evaluation with stereo-electroencephalography: a systematic review

S Hannan, A Ho, B Frauscher - Journal of Clinical …, 2024 - journals.lww.com
Although the role of sleep in modulating epileptic activity is well established, many
epileptologists overlook the significance of considering sleep during presurgical epilepsy …

Sleep, oscillations, and epilepsy

C Bernard, B Frauscher, J Gelinas, I Timofeev - Epilepsia, 2023 - Wiley Online Library
Sleep and wake are defined through physiological and behavioral criteria and can be
typically separated into non‐rapid eye movement (NREM) sleep stages N1, N2, and N3 …

[HTML][HTML] Resting-state background features demonstrate multidien cycles in long-term EEG device recordings

WKS Ojemann, BH Scheid, S Mouchtaris, A Lucas… - Brain Stimulation, 2023 - Elsevier
Background Longitudinal EEG recorded by implanted devices is critical for understanding
and managing epilepsy. Recent research reports patient-specific, multi-day cycles in device …

[HTML][HTML] A spatial perturbation framework to validate implantation of the epileptogenic zone

K Jaber, T Avigdor, D Mansilla, A Ho, J Thomas… - Nature …, 2024 - nature.com
Stereo-electroencephalography (SEEG) is the gold standard to delineate surgical targets in
focal drug-resistant epilepsy. SEEG uses electrodes placed directly into the brain to identify …

Pathological neurons generate ripples at the UP‐DOWN transition disrupting information transfer

SA Weiss, I Fried, J Engel Jr, A Bragin, S Wang… - …, 2024 - Wiley Online Library
Objective To confirm and investigate why pathological high‐frequency oscillations (pHFOs),
including ripples (80–200 Hz) and fast ripples (200–600 Hz), are generated during the UP …

The seizure severity score: a quantitative tool for comparing seizures and their response to therapy

AR Pattnaik, NJ Ghosn, IZ Ong, AY Revell… - Journal of Neural …, 2023 - iopscience.iop.org
Objective. Epilepsy is a neurological disorder characterized by recurrent seizures which vary
widely in severity, from clinically silent to prolonged convulsions. Measuring severity is …

Timing matters for accurate identification of the epileptogenic zone

B Chybowski, P Klimes, J Cimbalnik, V Travnicek… - Clinical …, 2024 - Elsevier
Objective Interictal biomarkers of the epileptogenic zone (EZ) and their use in machine
learning models open promising avenues for improvement of epilepsy surgery evaluation …

[HTML][HTML] Utility of intracranial EEG networks depends on re-referencing and connectivity choice

H Shi, AR Pattnaik, C Aguila, A Lucas… - Brain …, 2024 - academic.oup.com
Studies of intracranial EEG networks have been used to reveal seizure generators in
patients with drug-resistant epilepsy. Intracranial EEG is implanted to capture the epileptic …

Rapid eye movement sleep and epilepsy: exploring interactions and therapeutic prospects

L Nobili, R Cordani, D Arnaldi, P Mattioli… - Journal of Sleep …, 2024 - Wiley Online Library
While research interest in the relationship between sleep and epilepsy is growing, it
primarily centres on the effects of non‐rapid eye movement (NREM) sleep in favouring …