The development of the vertebrate eyes is a complex process starting from anterior-posterior
and dorso-ventral patterning of the anterior neural tube, resulting in the formation of the eye …

Three embryonic tissue sources—the neural ectoderm, the surface ectoderm, and the
periocular mesenchyme—contribute to the formation of the mammalian eye. For this reason …

The retinal pigment epithelium (RPE) is a simple epithelium interposed between the neural
retina and the choroid. Although only 1 cell-layer in thickness, the RPE is a virtual …

Eye development has been a paradigm for the study of organogenesis, from the
demonstration of lens induction through epithelial tissue morphogenesis, to neuronal …

Ocular lens development represents an advantageous system in which to study regulatory
mechanisms governing cell fate decisions, extracellular signaling, cell and tissue …

Neural crest cells (NCCs) are vertebrate‐specific transient, multipotent, migratory stem cells
that play a crucial role in many aspects of embryonic development. These cells emerge from …

Vertebrate retinal pigment epithelium (RPE) cells are derived from the multipotent optic
neuroepithelium, develop in close proximity to the retina, and are indispensible for eye …

Retinoic acid (RA) is a biologically active metabolite of vitamin A (retinol) that serves as a
signaling molecule during a number of developmental and physiological processes. RA …

Cone photoreceptor diversity allows detection of wavelength information in light, the first
step in color (chromatic) vision. In most mammals, cones express opsin photopigments for …

The separation of the optic neuroepithelium into future retina and retinal pigment epithelium
(RPE) is a critical event in early eye development in vertebrates. Here we show in mice that …