Dopamine and addiction: what have we learned from 40 years of research
Among the neurotransmitters involved in addiction, dopamine (DA) is clearly the best known.
The critical role of DA in addiction is supported by converging evidence that has been …
The critical role of DA in addiction is supported by converging evidence that has been …
Neurobiology of addiction versus drug use driven by lack of choice
Research on the neurobiology of addiction often involves nonhuman animals that are given
ready access to drugs for self-administration but without other choices. Here we argue using …
ready access to drugs for self-administration but without other choices. Here we argue using …
Pronounced hyperactivity, cognitive dysfunctions, and BDNF dysregulation in dopamine transporter knock-out rats
Dopamine (DA) controls many vital physiological functions and is critically involved in
several neuropsychiatric disorders such as schizophrenia and attention deficit hyperactivity …
several neuropsychiatric disorders such as schizophrenia and attention deficit hyperactivity …
Regulation of dopamine transporter function by protein‐protein interactions: new discoveries and methodological challenges
J. Neurochem.(2010) 10.1111/j. 1471‐4159.2010. 06599. x Abstract The dopamine
transporter (DAT) plays a key role in regulating dopaminergic signalling in the brain by …
transporter (DAT) plays a key role in regulating dopaminergic signalling in the brain by …
Psychostimulants affect dopamine transmission through both dopamine transporter-dependent and independent mechanisms
I dela Peña, R Gevorkiana, WX Shi - European journal of pharmacology, 2015 - Elsevier
The precise mechanisms by which cocaine and amphetamine-like psychostimulants exert
their reinforcing effects are not yet fully defined. It is widely believed, however, that these …
their reinforcing effects are not yet fully defined. It is widely believed, however, that these …
Innate immune signaling in the ventral tegmental area contributes to drug-primed reinstatement of cocaine seeking
KT Brown, SC Levis, CE O'Neill, AL Northcutt… - Brain, behavior, and …, 2018 - Elsevier
Cocaine addiction is a chronic relapsing disorder characterized by persistent perturbations
to an organism's homeostatic processes that result in maladaptive drug seeking. Although …
to an organism's homeostatic processes that result in maladaptive drug seeking. Although …
[HTML][HTML] Cocaine-induced endocannabinoid mobilization in the ventral tegmental area
Cocaine is a highly addictive drug that acts upon the brain's reward circuitry via the inhibition
of monoamine uptake. Endogenous cannabinoids (eCB) are lipid molecules released from …
of monoamine uptake. Endogenous cannabinoids (eCB) are lipid molecules released from …
Dopaminergic control of anxiety in young and aged zebrafish
Abstract Changes in the expression of the dopamine transporter (DAT), or the sensitivity of
dopamine receptors, are associated with aging and substance abuse and may underlie …
dopamine receptors, are associated with aging and substance abuse and may underlie …
[HTML][HTML] Drug-driven AMPA receptor redistribution mimicked by selective dopamine neuron stimulation
Background Addictive drugs have in common that they cause surges in dopamine (DA)
concentration in the mesolimbic reward system and elicit synaptic plasticity in DA neurons of …
concentration in the mesolimbic reward system and elicit synaptic plasticity in DA neurons of …
Dopamine transporter mutant animals: a translational perspective
EV Efimova, RR Gainetdinov, EA Budygin… - Journal of …, 2016 - Taylor & Francis
The dopamine transporter (DAT) plays an important homeostatic role in the control of both
the extracellular and intraneuronal concentrations of dopamine, thereby providing effective …
the extracellular and intraneuronal concentrations of dopamine, thereby providing effective …