Tumors are comprised of both cancer cells and surrounding stromal components. As an
essential part of the tumor microenvironment, the tumor stroma is highly dynamic …

The extracellular matrix is perturbed in tumors. The tumor matrix promotes the growth,
survival, and invasion of the cancer and modifies fibroblast and immune cell behavior to …

Kallikrein-related peptidases (KLKs) are critical regulators of the tumour microenvironment.
KLKs are proteolytic enzymes regulating multiple functions of bioactive molecules including …

Despite the steady increase in the number of studies focusing on the development of tissue
engineered constructs, solutions delivered to the clinic are still limited. Specifically, the lack …

Blood and lymphatic vessels are lined by endothelial cells which constantly interact with
their luminal and abluminal extracellular environments. These interactions confer physical …

While considerable progress has been made in studying genetic and cellular aspects of
metastasis with in vitro cell culture and in vivo animal models, the driving mechanisms of …

Blood vessels are constantly exposed to mechanical stimuli such as shear stress due to flow
and pulsatile stretch. The extracellular matrix maintains the structural integrity of the vessel …

Cell-cycle progression and division are fundamental biological processes in animal cells,
and their biochemical regulation has been extensively studied. An emerging body of work …

Hydrogels are effective platforms for use as artificial extracellular matrices, cell carriers, and
to present bioactive cues. Two common natural polymers, fibrin and alginate, are broadly …

The endothelial cells that compose the vascular system in the body display a wide range of
mechanotransductive behaviors and responses to biomechanical stimuli, which act in …