Decades of experimental work have established an imbalance of excitation and inhibition as
the leading mechanism of the transition from normal brain function to seizure. In epilepsy …

Posttranscriptional gene expression including splicing, RNA transport, translation, and RNA
decay provides an important regulatory layer in many if not all molecular pathways …

Astrocytes are the most abundant cell type in the brain, where they perform a wide array of
functions, yet the nature of their cellular heterogeneity and how it oversees these diverse …

A growing number of genomic tools and databases were developed to facilitate the
interpretation of genomic variants, particularly in coding regions. However, these tools are …

Objective Pathogenic variants of KCNQ 2, which encode a potassium channel subunit,
cause either benign (familial) neonatal epilepsy—B (F) NE)—or KCNQ 2 encephalopathy …

ASH1L, a histone methyltransferase, is identified as a top-ranking risk factor for autism
spectrum disorder (ASD), however, little is known about the biological mechanisms …

Mechanisms underlying seizures and epilepsy have traditionally been considered to involve
abnormalities of ion channels or synaptic function. Those considerations gave rise to the …

Circular RNAs (circRNAs), a class of long noncoding RNAs, are known to be enriched in
mammalian neural tissues. Although a wide range of dysregulation of gene expression in …

MYT1L is an autism spectrum disorder (ASD)-associated transcription factor that is
expressed in virtually all neurons throughout life. How MYT1L mutations cause neurological …

SoxB1 genes play fundamental roles in neurodevelopmental processes and maintaining
stem cell multipotency, but little is known about their function in regeneration. We addressed …