Protein post-translational modification (PTM) is a ubiquitousprocess thatoccurs in most
proteins. Lysine residues containing an ε-amino group are recognized as hotspots for the …

Genetic recombination is a common evolutionary mechanism that produces molecular
diversity. However, its consequences on protein folding stability have not attracted the same …

Abstract Changes that occur in proteins over time provide a phylogenetic signal that can be
used to decipher their evolutionary history and the relationships between organisms …

Variants in the genes encoding gamma‐aminobutyric acid type A (GABAA) receptor
subunits are associated with epilepsy. To date, over 1000 clinical variants have been …

An amino acid insertion or deletion, or InDel, can have profound and varying functional
impacts on a protein's structure. InDel mutations in the transmembrane conductor regulator …

Computational structural biology has demonstrated a key role in improving human health.
By harnessing big data techniques and machine learning methods, computational structural …

Understanding how amino acid insertion or deletion (InDel) mutations affect a protein's
structure can inform pharmaceutical efforts targeting diseases that are caused by protein …

The focus of this research is to investigate the effects of allostery on the function/activity of an
enzyme, human immunodeficiency virus type 1 (HIV-1) protease, using well-defined …