The nucleus accumbens is a major input structure of the basal ganglia and integrates
information from cortical and limbic structures to mediate goal-directed behaviors. Chronic …

Addiction is characterized as a chronic relapsing disorder whereby addicted individuals
persistently engage in drug seeking and use despite profound negative consequences. The …

Women are more sensitive to cocaine craving elicited by stimuli associated with relapse.
Ovarian hormones modulate cocaine craving and may therefore function as risk factors or …

The detrimental effects of drug abuse are apparently not limited to individuals but may also
impact the vulnerability of their progenies to develop addictive behaviours. Epigenetic …

Background N-acetylcysteine (NAC) has been suggested to prevent relapse to cocaine
seeking. However, the psychological processes underlying its potential therapeutic benefit …

N-acetylcysteine and bupropion are two promising candidate medications for treatment of
substance use disorder. The effects of N-acetylcysteine or bupropion on methamphetamine …

Rationale Accumulating evidence shows that cocaine, and also heroin, influence several
tyrosine kinases, expressed in neurons and in non-neuronal populations such as microglia …

Glutamatergic imbalances are characteristic of SUDs. Astrocytic and neuronal transporters
help regulate glutamate homeostasis and disruptions in this homeostasis engender SUD …

In dealing with a rampant increase in addiction to whoonga or nyaope, a heroin variant drug
that has taken hold amongst Black youth in South African townships, the employment of …

Anorexia nervosa (AN) is a disease affecting mainly young women. It involves a pathological
desire to be thin and has a complex etiology. Treatments, which have varying degrees of …