Notch signaling is an evolutionarily highly conserved signaling mechanism, but in contrast to
signaling pathways such as Wnt, Sonic Hedgehog, and BMP/TGF-β, Notch signaling occurs …

Notch signaling is a conserved system of communication between adjacent cells,
influencing numerous cell fate decisions in the development of multicellular organisms …

The distal lung contains terminal bronchioles and alveoli that facilitate gas exchange. Three-
dimensional in vitro human distal lung culture systems would strongly facilitate the …

The extent to which cells in normal tissues accumulate mutations throughout life is poorly
understood. Some mutant cells expand into clones that can be detected by genome …

Adoptive cell therapy using engineered T cell receptors (TCRs) is a promising approach for
targeting cancer antigens, but tumor-reactive TCRs are often weakly responsive to their …

It is well established that cells sense chemical signals from their local microenvironment and
transduce them to the nucleus to regulate gene expression programmes. Although a number …

Fucose is a 6-deoxy hexose in the l-configuration found in a large variety of different
organisms. In mammals, fucose is incorporated into N-glycans, O-glycans and glycolipids by …

TCR-signaling strength generally correlates with peptide-MHC binding affinity; however,
exceptions exist. We find high-affinity, yet non-stimulatory, interactions occur with high …

The Notch signaling pathway relies on a proteolytic cascade to release its transcriptionally
active intracellular domain, on force to unfold a protective domain and permit proteolysis, on …

Mechanosensing describes the ability of a cell to sense mechanical cues of its
microenvironment, including not only all components of force, stress, and strain but also …