Altered metabolic activity contributes to the pathogenesis of a number of diseases, including
diabetes, heart failure, cancer, fibrosis and neurodegeneration. These diseases, and …

Lung transplantation, a cure for a number of end-stage lung diseases, continues to have the
worst long-term outcomes when compared with other solid organ transplants. Preclinical …

Neutrophil extracellular traps (NETs) have been shown to worsen acute pulmonary injury
including after lung transplantation. The breakdown of NETs by DNAse-1 can help restore …

Lung inflammatory diseases contribute significantly to the socioeconomic burden of disease.
Yet very few new, effective therapies for respiratory disease have been approved for use. A …

Ischemia-reperfusion injury–mediated primary graft dysfunction substantially hampers short-
and long-term outcomes after lung transplantation. This condition continues to be diagnosed …

Infectious and inflammatory pulmonary diseases are a leading cause of morbidity and
mortality worldwide. Although infrequently used in this setting, molecular imaging may …

Obliterative bronchiolitis (OB) is a poorly understood airway disease characterized by the
generation of fibrotic bronchiolar occlusions. In the lung transplant setting, OB is a …

Inflammatory lung disease is one of the most common clinical scenarios, and yet, it is often
poorly understood. Inflammatory lung disorders, such as chronic obstructive pulmonary …

Imaging holds an important role in the diagnosis of lung diseases. Along with clinical tests,
noninvasive imaging techniques provide complementary and valuable information that …

Kidney transplantation is the best available treatment for patients with end stage renal
disease. Despite the introduction of effective immunosuppressant drugs, episodes of acute …