Lysosomal biology and function: modern view of cellular debris bin
PC Trivedi, JJ Bartlett, T Pulinilkunnil - Cells, 2020 - mdpi.com
Lysosomes are the main proteolytic compartments of mammalian cells comprising of a
battery of hydrolases. Lysosomes dispose and recycle extracellular or intracellular …
battery of hydrolases. Lysosomes dispose and recycle extracellular or intracellular …
[HTML][HTML] COVID-19-associated cardiovascular morbidity in older adults: a position paper from the Italian Society of Cardiovascular Researches
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infects host cells following
binding with the cell surface ACE2 receptors, thereby leading to coronavirus disease 2019 …
binding with the cell surface ACE2 receptors, thereby leading to coronavirus disease 2019 …
Essential requirement for JPT2 in NAADP-evoked Ca2+ signaling
GS Gunaratne, E Brailoiu, S He, EM Unterwald… - Science …, 2021 - science.org
Nicotinic acid adenine dinucleotide phosphate (NAADP) is a second messenger that
releases Ca2+ from acidic organelles through the activation of two-pore channels (TPCs) to …
releases Ca2+ from acidic organelles through the activation of two-pore channels (TPCs) to …
Structure of the voltage-gated two-pore channel TPC1 from Arabidopsis thaliana
Two-pore channels (TPCs) contain two copies of a Shaker-like six-transmembrane (6-TM)
domain in each subunit and are ubiquitously expressed in both animals and plants as …
domain in each subunit and are ubiquitously expressed in both animals and plants as …
Convergent activation of Ca2+ permeability in two-pore channel 2 through distinct molecular routes
R Saito, Q Mu, Y Yuan, M Rubio-Alarcón… - Science …, 2023 - science.org
TPC2 is a pathophysiologically relevant lysosomal ion channel that is activated directly by
the phosphoinositide PI (3, 5) P2 and indirectly by the calcium ion (Ca2+)–mobilizing …
the phosphoinositide PI (3, 5) P2 and indirectly by the calcium ion (Ca2+)–mobilizing …
Structural insights into the voltage and phospholipid activation of the mammalian TPC1 channel
The organellar two-pore channel (TPC) functions as a homodimer, in which each subunit
contains two homologous Shaker-like six-transmembrane (6-TM)-domain repeats. TPCs …
contains two homologous Shaker-like six-transmembrane (6-TM)-domain repeats. TPCs …
Structure, inhibition and regulation of two-pore channel TPC1 from Arabidopsis thaliana
AF Kintzer, RM Stroud - Nature, 2016 - nature.com
Two-pore channels (TPCs) comprise a subfamily (TPC1–3) of eukaryotic voltage-and ligand-
gated cation channels, with two non-equivalent tandem pore-forming subunits that dimerize …
gated cation channels, with two non-equivalent tandem pore-forming subunits that dimerize …
NAADP-dependent Ca2+ signaling regulates Middle East respiratory syndrome-coronavirus pseudovirus translocation through the endolysosomal system
GS Gunaratne, Y Yang, F Li, TF Walseth, JS Marchant - Cell Calcium, 2018 - Elsevier
Abstract Middle East Respiratory Syndrome coronavirus (MERS-CoV) infections are
associated with a significant mortality rate, and existing drugs show poor efficacy. Identifying …
associated with a significant mortality rate, and existing drugs show poor efficacy. Identifying …
Function and dysfunction of two-pore channels
S Patel - Science signaling, 2015 - science.org
Two-pore channels (TPCs) are evolutionarily important members of the voltage-gated ion
channel superfamily. TPCs localize to acidic Ca2+ stores within the endolysosomal system …
channel superfamily. TPCs localize to acidic Ca2+ stores within the endolysosomal system …
Segregated cation flux by TPC2 biases Ca2+ signaling through lysosomes
Two-pore channels are endo-lysosomal cation channels with malleable selectivity filters that
drive endocytic ion flux and membrane traffic. Here we show that TPC2 can differentially …
drive endocytic ion flux and membrane traffic. Here we show that TPC2 can differentially …