Solving inverse scattering problems in biological samples by quantitative phase imaging

T Kim, R Zhou, LL Goddard… - Laser & Photonics …, 2016 - Wiley Online Library
Quantitative phase imaging (QPI), a method that precisely recovers the wavefront of an
electromagnetic field scattered by a transparent, weakly scattering object, is a rapidly …

Quantitative phase imaging

M Mir, B Bhaduri, R Wang, R Zhu, G Popescu - Progress in optics, 2012 - Elsevier
Quantitative phase imaging (QPI) is an emerging field aimed at studying weakly scattering
and absorbing specimens (Popescu, 2011). The main challenge in generating intrinsic …

New technologies for measuring single cell mass

G Popescu, K Park, M Mir, R Bashir - Lab on a Chip, 2014 - pubs.rsc.org
Characterizing the physical properties of single cells is of great interest for unraveling the
heterogeneity in a cell population. Recent advances in micro-systems technologies and …

Quantitative phase imaging (QPI) in neuroscience

C Hu, G Popescu - IEEE Journal of Selected Topics in Quantum …, 2018 - ieeexplore.ieee.org
Quantitative phase imaging (QPI) is an emerging label-free modality that attracts significant
interest in biomedicine in general and neuroscience in particular. Based on the principle of …

Real time blood testing using quantitative phase imaging

HV Pham, B Bhaduri, K Tangella, C Best-Popescu… - PloS one, 2013 - journals.plos.org
We demonstrate a real-time blood testing system that can provide remote diagnosis with
minimal human intervention in economically challenged areas. Our instrument combines …

Dispersion-relation phase spectroscopy of intracellular transport

R Wang, Z Wang, L Millet, MU Gillette, AJ Levine… - Optics …, 2011 - opg.optica.org
We used quantitative phase imaging to measure the dispersion relation, ie decay rate vs.
spatial mode, associated with mass transport in live cells. This approach applies equally …

Label-free characterization of emerging human neuronal networks

M Mir, T Kim, A Majumder, M Xiang, R Wang, SC Liu… - Scientific reports, 2014 - nature.com
The emergent self-organization of a neuronal network in a developing nervous system is the
result of a remarkably orchestrated process involving a multitude of chemical, mechanical …

Label-free tissue scanner for colorectal cancer screening

ME Kandel, S Sridharan, J Liang, Z Luo… - … of biomedical optics, 2017 - spiedigitallibrary.org
The current practice of surgical pathology relies on external contrast agents to reveal tissue
architecture, which is then qualitatively examined by a trained pathologist. The diagnosis is …

Optical excitation and detection of neuronal activity

C Hu, R Sam, M Shan, V Nastasa, M Wang… - Journal of …, 2019 - Wiley Online Library
Optogenetics has emerged as an exciting tool for manipulating neural activity, which in turn,
can modulate behavior in live organisms. However, detecting the response to the optical …

Spatial Light Interference Microscopy (SLIM) using twisted-nematic liquid-crystal modulation

TH Nguyen, G Popescu - Biomedical optics express, 2013 - opg.optica.org
We report the use of a twisted nematic liquid-crystal spatial light modulator (TNLC-SLM) for
quantitative phase imaging. The experimental setup is a new implementation of the SLIM …