Non-genetic alterations can produce changes in a cell's phenotype. In cancer, these
phenomena can influence a cell's fitness by conferring access to heritable, beneficial …

Metastasis is a multistep process by which cancer cells break away from their original
location and spread to distant organs, and is responsible for the vast majority of cancer …

Glioma cells hijack developmental programs to control cell state. Here, we uncover a glioma
cell state-specific metabolic liability that can be therapeutically targeted. To model cell …

Glioblastoma (GBM) is a deadly brain tumor, and the kinesin motor KIF11 is an attractive
therapeutic target with roles in proliferation and invasion. Resistance to KIF11 inhibitors …

Recent advances in cancer biology and therapeutics have underscored the importance of
preclinical models in understanding and treating cancer. Nevertheless, current models often …

Deciphering the landscape of transcriptional heterogeneity across cancer: Cancer Cell Skip to
Main Content Advertisement Cancer Cell This journal offers authors two options (open access or …

Lineage tracing has significantly advanced our comprehension in many areas of biology,
such as development or immunity, by precisely measuring cellular processes like migration …

Single-cell RNA sequencing (scRNA-seq) has transformed our understanding of phenotypic
heterogeneity. Although the predominant focus of scRNA-seq analyses has been assessing …

Understanding cellular birth rate differences is crucial for predicting cancer progression and
interpreting tumor-derived genetic data. Lineage tracing experiments enable detailed …