Brain molecular connectivity in neurodegenerative diseases: recent advances and new perspectives using positron emission tomography

A Sala, D Perani - Frontiers in neuroscience, 2019 - frontiersin.org
Positron emission tomography (PET) represents a unique molecular tool to get in vivo
access to a wide spectrum of biological and neuropathological processes, of crucial …

Alzheimer's disease, a lipid story: involvement of peroxisome proliferator-activated receptor α

F Sáez-Orellana, JN Octave, N Pierrot - Cells, 2020 - mdpi.com
Alzheimer's disease (AD) is the leading cause of dementia in the elderly. Mutations in genes
encoding proteins involved in amyloid-β peptide (Aβ) production are responsible for …

Clozapine induces astrocyte-dependent FDG-PET hypometabolism

A Rocha, B Bellaver, DG Souza, G Schu… - European Journal of …, 2022 - Springer
Purpose Advances in functional imaging allowed us to visualize brain glucose metabolism
in vivo and non-invasively with [18F] fluoro-2-deoxyglucose (FDG) positron emission …

The application of intelligent data models for dementia classification

R AlShboul, F Thabtah, AJ Walter Scott, Y Wang - Applied Sciences, 2023 - mdpi.com
Background and Objective Background and Objective: Dementia is a broad term for a
complex range of conditions that affect the brain, such as Alzheimer's disease (AD) …

Validation of FDG-PET datasets of normal controls for the extraction of SPM-based brain metabolism maps

SP Caminiti, A Sala, L Presotto, A Chincarini… - European journal of …, 2021 - Springer
Purpose An appropriate healthy control dataset is mandatory to achieve good performance
in voxel-wise analyses. We aimed at evaluating [18F] FDG PET brain datasets of healthy …

A comprehensive review on detection and classification of dementia using neuroimaging and machine learning

N Pateria, D Kumar - Multimedia Tools and Applications, 2024 - Springer
Dementia, not a particular disease but rather a gathering of conditions which ascribes the
debilitation of atleast two cerebrum capacities, cognitive decline and memory judgment has …

Brain metabolic signatures across the Alzheimer's disease spectrum

A Sala, C Caprioglio, R Santangelo, EG Vanoli… - European journal of …, 2020 - Springer
Purpose Given the challenges posed by the clinical diagnosis of atypical Alzheimer's
disease (AD) variants and the limited imaging evidence available in the prodromal phases …

CSF p-tau/Aβ42 ratio and brain FDG-PET may reliably detect MCI “imminent” converters to AD

R Santangelo, F Masserini, F Agosta, A Sala… - European Journal of …, 2020 - Springer
Purpose To know whether mild cognitive impairment (MCI) patients will develop Alzheimer's
disease (AD) dementia in very short time or remain stable is of crucial importance, also …

High-Fat Diets in Animal Models of Alzheimer's Disease: How Can Eating Too Much Fat Increase Alzheimer's Disease Risk?

J Valentin-Escalera, M Leclerc… - Journal of Alzheimer's …, 2024 - content.iospress.com
High dietary intake of saturated fatty acids is a suspected risk factor for neurodegenerative
diseases, including Alzheimer's disease (AD). To decipher the causal link behind these …

In vivo MRI structural and PET metabolic connectivity study of dopamine pathways in Alzheimer's disease

L Iaccarino, A Sala, SP Caminiti… - Journal of …, 2020 - content.iospress.com
Background: Alzheimer's disease (AD) is characterized by an involvement of brain
dopamine (DA) circuitry, the presence of which has been associated with emergence of both …