CRISPR/Cas-Dependent and Nuclease-Free In Vivo Therapeutic Gene Editing
Precise gene manipulation by gene editing approaches facilitates the potential to cure
several debilitating genetic disorders. Gene modification stimulated by engineered …
several debilitating genetic disorders. Gene modification stimulated by engineered …
CRISPR/Cas9 targeting events cause complex deletions and insertions at 17 sites in the mouse genome
Although CRISPR/Cas9 genome editing has provided numerous opportunities to interrogate
the functional significance of any given genomic site, there is a paucity of data on the extent …
the functional significance of any given genomic site, there is a paucity of data on the extent …
Zinc: An element of extensive medical importance
Zinc is an element of great biological significance. Many biochemical processes cannot
occur without zinc as it is required for large number of physiological functions. It plays an …
occur without zinc as it is required for large number of physiological functions. It plays an …
Advancements in developing strategies for sterilizing and functional HIV cures
Combined antiretroviral therapy (cART) has been successful in prolonging lifespan and
reducing mortality of patients infected with human immunodeficiency virus (HIV). However …
reducing mortality of patients infected with human immunodeficiency virus (HIV). However …
Genome editing strategies: potential tools for eradicating HIV-1/AIDS
K Khalili, R Kaminski, J Gordon, L Cosentino… - Journal of …, 2015 - Springer
Current therapy for controlling human immunodeficiency virus (HIV-1) infection and
preventing acquired immunodeficiency syndrome (AIDS) progression has profoundly …
preventing acquired immunodeficiency syndrome (AIDS) progression has profoundly …
Detection of treatment-resistant infectious HIV after genome-directed antiviral endonuclease therapy
Incurable chronic viral infections are a major cause of morbidity and mortality worldwide.
One potential approach to cure persistent viral infections is via the use of targeted …
One potential approach to cure persistent viral infections is via the use of targeted …
[HTML][HTML] CRISPR-Cas12b enables a highly efficient attack on HIV proviral DNA in T cell cultures
M Fan, Y Bao, B Berkhout, E Herrera-Carrillo - Biomedicine & …, 2023 - Elsevier
Abstract Background The novel endonuclease Cas12b was engineered for targeted
genome editing in mammalian cells and is a promising tool for certain applications because …
genome editing in mammalian cells and is a promising tool for certain applications because …
Enhancing broadly neutralising antibody suppression of HIV by immune modulation and vaccination
C Nel, J Frater - Frontiers in Immunology, 2024 - frontiersin.org
Although HIV infection can be managed with antiretroviral drugs, there is no cure and
therapy has to be taken for life. Recent successes in animal models with HIV-specific …
therapy has to be taken for life. Recent successes in animal models with HIV-specific …
Novel AIDS therapies based on gene editing
K Khalili, MK White, JM Jacobson - Cellular and Molecular Life Sciences, 2017 - Springer
HIV/AIDS remains a major public health issue. In 2014, it was estimated that 36.9 million
people are living with HIV worldwide, including 2.6 million children. Since the advent of …
people are living with HIV worldwide, including 2.6 million children. Since the advent of …
[HTML][HTML] Zinc finger nuclease: a new approach to overcome beta-lactam antibiotic resistance
MS Dastjerdeh, S Kouhpayeh, F Sabzehei… - Jundishapur Journal …, 2016 - ncbi.nlm.nih.gov
Background: The evolution of antibiotic-resistant bacteria (ARB) and antibiotic-resistance
genes (ARGs) has been accelerated recently by the indiscriminate application of antibiotics …
genes (ARGs) has been accelerated recently by the indiscriminate application of antibiotics …