The group IV phospholipase A 2 (PLA 2) family is comprised of six intracellular enzymes
(GIVA,-B,-C,-D,-E, and-F) commonly referred to as cytosolic PLA 2 (cPLA 2) α,-β,-γ,-δ,-ε, and …

Nonsteroidal anti-inflammatory drugs (NSAIDs) represent one of the most highly utilized
classes of pharmaceutical agents in medicine. All NSAIDs act through inhibiting …

The molecular pathology of multi-organ injuries in COVID-19 patients remains unclear,
preventing effective therapeutics development. Here, we report a proteomic analysis of 144 …

Tissue stiffening is a hallmark of fibrotic disorders but has traditionally been regarded as an
outcome of fibrosis, not a contributing factor to pathogenesis. In this study, we show that …

Platelet-derived growth factor (PDGF) isoforms play a major role in stimulating the
replication, survival, and migration of myofibroblasts during the pathogenesis of fibrotic …

Prostanoids represent a group of lipid mediators that are produced from arachidonic acid via
the cyclooxygenase pathway. Once formed, the prostanoids are released from the cells and …

Idiopathic pulmonary fibrosis (IPF) is a progressive lung disease of unknown etiology
characterized by distorted distal lung architecture, inflammation, and fibrosis. The molecular …

Abstract Prostaglandin E 2 (PGE 2) is commonly considered a potent proinflammatory
mediator and is involved in several inflammatory diseases. In the lung, as opposed to many …

We examined the in vivo role of membrane-bound prostaglandin E synthase (mPGES)-1, a
terminal enzyme in the PGE 2-biosynthetic pathway, using mPGES-1 knockout (KO) mice …

The activation of macrophages through Toll-like receptor (TLR) pathways leads to the
production of a broad array of cytokines and mediators that coordinate the immune …