Network pharmacology databases for traditional Chinese medicine: review and assessment

R Zhang, X Zhu, H Bai, K Ning - Frontiers in pharmacology, 2019 - frontiersin.org
The research field of systems biology has greatly advanced and, as a result, the concept of
network pharmacology has been developed. This advancement, in turn, has shifted the …

Plant-derived natural products for drug discovery: current approaches and prospects

N Nasim, IS Sandeep, S Mohanty - The Nucleus, 2022 - Springer
Nature has abundant source of drugs that need to be identified/purified for use as essential
biologics, either individually or in combination in the modern medical field. These drugs are …

ETCM: an encyclopaedia of traditional Chinese medicine

HY Xu, YQ Zhang, ZM Liu, T Chen, CY Lv… - Nucleic acids …, 2019 - academic.oup.com
Traditional Chinese medicine (TCM) is not only an effective solution for primary health care,
but also a great resource for drug innovation and discovery. To meet the increasing needs …

IMPPAT: A curated database of I ndian M edicinal P lants, P hytochemistry A nd T herapeutics

K Mohanraj, BS Karthikeyan, RP Vivek-Ananth… - Scientific reports, 2018 - nature.com
Phytochemicals of medicinal plants encompass a diverse chemical space for drug
discovery. India is rich with a flora of indigenous medicinal plants that have been used for …

Advancing computer-aided drug discovery (CADD) by big data and data-driven machine learning modeling

L Zhao, HL Ciallella, LM Aleksunes, H Zhu - Drug discovery today, 2020 - Elsevier
Highlights•Drug discovery has been advanced to a big data era with a large amount of
public data sources available.•Ten V features (volume, velocity, variety, veracity, validity …

IMPPAT 2.0: An enhanced and expanded phytochemical atlas of Indian medicinal plants

RP Vivek-Ananth, K Mohanraj, AK Sahoo, A Samal - ACS omega, 2023 - ACS Publications
Compilation, curation, digitization, and exploration of the phytochemical space of Indian
medicinal plants can expedite ongoing efforts toward natural product and traditional …

HIT 2.0: an enhanced platform for Herbal Ingredients' Targets

D Yan, G Zheng, C Wang, Z Chen, T Mao… - Nucleic acids …, 2022 - academic.oup.com
Literature-described targets of herbal ingredients have been explored to facilitate the
mechanistic study of herbs, as well as the new drug discovery. Though several databases …

The methodological trends of traditional herbal medicine employing network pharmacology

WY Lee, CY Lee, YS Kim, CE Kim - Biomolecules, 2019 - mdpi.com
Natural products, including traditional herbal medicine (THM), are known to exert their
therapeutic effects by acting on multiple targets, so researchers have employed network …

Multi-layer information fusion based on graph convolutional network for knowledge-driven herb recommendation

Y Yang, Y Rao, M Yu, Y Kang - Neural Networks, 2022 - Elsevier
Abstract Prescription of Traditional Chinese Medicine (TCM) is a precious treasure
accumulated in the long-term development of TCM. Artificial intelligence (AI) technology is …

iGRLCDA: identifying circRNA–disease association based on graph representation learning

HY Zhang, L Wang, ZH You, L Hu… - Briefings in …, 2022 - academic.oup.com
While the technologies of ribonucleic acid-sequence (RNA-seq) and transcript assembly
analysis have continued to improve, a novel topology of RNA transcript was uncovered in …