Organoids are three‐dimensional (3D) miniaturized versions of organs or tissues that are
derived from cells with stem potential and can self‐organize and differentiate into 3D cell …

Understanding of human brain development, dysfunction and neurological diseases has
remained limited and challenging due to inability to recapitulate human brain-specific …

The C allele of rs11136000 variant in the clusterin (CLU) gene represents the third strongest
known genetic risk factor for late-onset Alzheimer's disease. However, whether this single …

Th17/Treg imbalance is closely related to the occurrence and development of multiple
sclerosis (MS), and the transdifferentiation of Th17 cells into Treg cells may contribute to the …

Progression of Alzheimer's disease (AD) entails deterioration or aberrant function of multiple
brain cell types, eventually leading to neurodegeneration and cognitive decline. Defining …

Although historically, the traditional bidimensional in vitro cell system has been widely used
in research, providing much fundamental information regarding cellular functions and …

At the level of in vitro drug screening, the development of a phenotypic analysis system with
high-content screening at the core provides a strong platform to support high-throughput …

Thanks to progress in the development of three‐dimensional (3D) culture technologies,
human central nervous system (CNS) development and diseases have been gradually …

As a highly selective and semi-permeable barrier that separates the circulating blood from
the brain and central nervous system (CNS), the blood-brain barrier (BBB) plays a critical …

Neurodegenerative diseases are adult-onset neurological conditions that are notoriously
difficult to model for drug discovery and development because most models are unable to …