Natural products have been an invaluable and useful source of anticancer agents over the
years. Several compounds have been synthesized from natural products by modifying their …

Cancer is a complex multifactorial disease that results from alterations in many physiological
and biochemical functions. Over the last few decades, it has become clear that cancer cells …

Abstract Cyclin-dependent kinase 2 (CDK2) complex is significantly over-activated in many
cancers. While it makes CDK2 an attractive target for cancer therapy, most inhibitors against …

The majority of RUNX1 mutations in acute myeloid leukemia (AML) are missense or deletion-
truncation and behave as loss-of-function mutations. Following standard therapy, AML …

Leukemia is a heterogeneous group of hematological malignancies distinguished by
differentiation blockage and uncontrolled proliferation of myeloid or lymphoid progenitor …

It is becoming progressively more understandable that pharmaceutical targeting of drug-
resistant cancers is challenging because of intra-and inter-tumor heterogeneity …

The rapid advances in high‐throughput sequencing technologies have made it more evident
that epigenetic modifications orchestrate a plethora of complex biological processes. During …

Leukemia is a malignancy initiated by uncontrolled proliferation of hematopoietic stem cell
from the B and T lineages, resulting in destruction of hematopoietic system. The …

DNA methylation plays an important role in the silence of tissue-specific genes to prevent
them from being expressed in the wrong tissue. Aberrant DNA methylation (genome-wide …

Plants and natural compounds have been widely recognized to have potential for the
prevention of cancer progression and as complementary or standalone treatments for …