Acute pancreatitis: diagnosis and treatment

P Szatmary, T Grammatikopoulos, W Cai, W Huang… - Drugs, 2022 - Springer
Acute pancreatitis is a common indication for hospital admission, increasing in incidence,
including in children, pregnancy and the elderly. Moderately severe acute pancreatitis with …

The roles of calcium and ATP in the physiology and pathology of the exocrine pancreas

OH Petersen, JV Gerasimenko… - Physiological …, 2021 - journals.physiology.org
This review deals with the roles of calcium ions and ATP in the control of the normal
functions of the different cell types in the exocrine pancreas as well as the roles of these …

Cyclosporine modulates neutrophil functions via the SIRT6–HIF‐1α–glycolysis axis to alleviate severe ulcerative colitis

H Lu, J Lin, C Xu, M Sun, K Zuo… - Clinical and …, 2021 - Wiley Online Library
Abstract Background Cyclosporine A (CsA) is routinely used to treat patients with steroid‐
refractory acute severe ulcerative colitis (ASUC). Here, we studied the underlying …

New insights into the etiology, risk factors, and pathogenesis of pancreatitis in dogs: Potential impacts on clinical practice

H Cridge, SY Lim, H Algül… - Journal of Veterinary …, 2022 - Wiley Online Library
While most cases of pancreatitis in dogs are thought to be idiopathic, potential risk factors
are identified. In this article we provide a state‐of‐the‐art overview of suspected risk factors …

Experimental acute pancreatitis models: history, current status, and role in translational research

X Yang, L Yao, X Fu, R Mukherjee, Q Xia… - Frontiers in …, 2020 - frontiersin.org
Acute pancreatitis is a potentially severe inflammatory disease that may be associated with a
substantial morbidity and mortality. Currently there is no specific treatment for the disease …

Comprehensive mechanism, novel markers and multidisciplinary treatment of severe acute pancreatitis-associated cardiac injury–a narrative review

YL Luo, ZX Li, P Ge, HY Guo, L Li… - Journal of …, 2021 - Taylor & Francis
Acute pancreatitis (AP) is one of the common acute abdominal inflammatory diseases in
clinic with acute onset and rapid progress. About 20% of the patients will eventually develop …

[HTML][HTML] Colchicine improves severe acute pancreatitis-induced acute lung injury by suppressing inflammation, apoptosis and oxidative stress in rats

D Zhang, L Li, J Li, YL Wei, J Tang, X Man… - Biomedicine & …, 2022 - Elsevier
Background Inflammation, apoptosis and oxidative stress contribute to the development of
severe acute pancreatitis-associated acute lung injury (SAP-ALI). Currently, there is no …

Immune cells and immune cell-targeted therapy in chronic pancreatitis

Y Zhang, WQ Zhang, XY Liu, Q Zhang, T Mao… - Frontiers in …, 2023 - frontiersin.org
In recent years, studies have attempted to understand the immune cells and mechanisms
underlying the pathogenesis of chronic pancreatitis (CP) by constructing a model of CP …

[HTML][HTML] Calcineurin in development and disease

L Chen, M Song, C Yao - Genes & Diseases, 2022 - Elsevier
Calcineurin (CaN) is a unique calcium (Ca 2+) and calmodulin (CaM)-dependent
serine/threonine phosphatase that becomes activated in the presence of increased …

Saikosaponin A‐Induced Gut Microbiota Changes Attenuate Severe Acute Pancreatitis through the Activation of Keap1/Nrf2‐ARE Antioxidant Signaling

J Li, J Han, J Lv, S Wang, L Qu… - Oxidative Medicine and …, 2020 - Wiley Online Library
Objective. Severe acute pancreatitis (SAP) is a serious and life‐threatening disease
associated with multiple organ failure and a high mortality rate and is accompanied by …