siRNA therapeutics have gained extensive attention, and to date six siRNAs are approved
for clinical use. Despite being investigated for the treatment of metabolic, cardiovascular …

Circular RNAs are an unusual class of single-stranded RNAs whose ends are covalently
linked via back-splicing. Due to their versatility, the need to express circular RNAs in vivo …

Oligonucleotide-based therapeutics have attracted attention as an emerging modality that
includes the modulation of genes and their binding proteins related to diseases, allowing us …

RNA interference has become increasingly used for genetic therapy following the rapid
development of oligonucleotide drugs. Significant progress has been made in its delivery …

Synthetic small interfering RNAs conjugated to trivalent N-acetylgalactosamine (GalNAc) are
clinically validated drugs for treatment of liver diseases. Incorporation of phosphorothioate …

Simple Summary Arma chinensis (Fallou) is a predatory natural enemy that plays a vital role
in the biological control of various agricultural and forestry pests. In this study, the temporal …

World Health Organization (WHO) data show that of the top 20 factors that threaten human
life and health, cancer is at the forefront, and the therapeutic approaches for cancer consist …

To date, the US Food and Drug Administration (FDA) has approved six small interfering RNA
(siRNA) drugs: patisiran, givosiran, lumasiran, inclisiran, vutrisiran, and nedosiran, serving …

Lipophilic oligonucleotide derivatives are a potent approach to the intracellular delivery of
nucleic acids. The binding of these derivatives to serum albumin is a determinant of their fate …

Trigger-activatable antisense oligonucleotides have been widely applied to regulate gene
function. Among them, caged cyclic antisense oligonucleotides (cASOs) maintain a specific …