Heritable predisposition is an important cause of cancer in children and adolescents.
Although a large number of cancer predisposition genes and their associated syndromes …

Wilms tumour is the most common renal malignancy of childhood. The disease is curable in
the majority of cases, albeit at considerable cost in terms of late treatment-related effects in …

A number of genetic syndromes have been linked to increased risk for Wilms tumor (WT),
hepatoblastoma (HB), and other embryonal tumors. Here, we outline these rare syndromes …

Background Wilms tumour is the most common childhood renal cancer and is genetically
heterogeneous. While several Wilms tumour predisposition genes have been identified …

Progresses over the past years have extensively improved our capacity to use genome-
scale analyses—including high-density genotyping and exome and genome sequencing …

Pediatric renal tumors account for 3%–11% of childhood cancers, the most common of
which is Wilms tumor or nephroblastoma. Epidemiology plays a key role in cancer …

Since previous consensus-based Wilms tumour (WT) surveillance guidelines were
published, novel genes and syndromes associated with WT risk have been identified, and …

The additional sex combs-like (ASXL) gene family—encoded by ASXL1, ASXL2, and ASXL3—
is crucial for mammalian development. Pathogenic variants in the ASXL gene family are …

Wilms tumors are commonly associated with predisposition syndromes, many but not all of
which include overgrowth. Several of these syndromes also include a risk of other …

Familial colorectal cancer type X (FCCTX) is a heterogeneous colorectal cancer
predisposition syndrome that, although displays a cancer pattern similar to Lynch syndrome …