DLX Genes: Roles in Development and Cancer

Y Tan, JR Testa - Cancers, 2021 - mdpi.com
Simple Summary DLX homeobox family genes encode transcription factors that have
indispensable roles in embryonic and postnatal development. These genes are critically …

Genetic regulation of vertebrate forebrain development by homeobox genes

RF Leung, AM George, EM Roussel, MC Faux… - Frontiers in …, 2022 - frontiersin.org
Forebrain development in vertebrates is regulated by transcription factors encoded by
homeobox, bHLH and forkhead gene families throughout the progressive and overlapping …

The transcription factor MEF2C is required for craniofacial development

MP Verzi, P Agarwal, C Brown, DJ McCulley… - Developmental cell, 2007 - cell.com
MEF2 transcription factors are well-established regulators of muscle development. We have
discovered an unanticipated role for MEF2C in the neural crest, where tissue-specific …

Language impairments in ASD resulting from a failed domestication of the human brain

A Benítez-Burraco, W Lattanzi, E Murphy - Frontiers in Neuroscience, 2016 - frontiersin.org
Autism spectrum disorders (ASD) are pervasive neurodevelopmental disorders entailing
social and cognitive deficits, including marked problems with language. Numerous genes …

Downregulation of Dlx5 and Dlx6 expression by Hand2 is essential for initiation of tongue morphogenesis

F Barron, C Woods, K Kuhn, J Bishop… - …, 2011 - journals.biologists.com
Lower jaw development is a complex process in which multiple signaling cascades
establish a proximal-distal organization. These cascades are regulated both spatially and …

Globularization and domestication

A Benítez-Burraco, C Theofanopoulou, C Boeckx - Topoi, 2018 - Springer
This paper aims to explore a potential connection between two hypotheses recently put
forward in the context of language evolution. One hypothesis argues that some human …

Schizophrenia and human self-domestication: an evolutionary linguistics approach

A Benítez-Burraco, L Di Pietro, M Barba… - Brain, behavior and …, 2017 - karger.com
Schizophrenia (SZ) is a pervasive neurodevelopmental disorder that entails social and
cognitive deficits, including marked language problems. Its complex multifactorial …

Inferring novel tumor suppressor genes with a protein-protein interaction network and network diffusion algorithms

L Chen, YH Zhang, Z Zhang, T Huang… - … Therapy Methods & …, 2018 - cell.com
Extensive studies on tumor suppressor genes (TSGs) are helpful to understand the
pathogenesis of cancer and design effective treatments. However, identifying TSGs using …

Active intermixing of indirect and direct neurons builds the striatal mosaic

A Tinterri, F Menardy, MA Diana, L Lokmane… - Nature …, 2018 - nature.com
The striatum controls behaviors via the activity of direct and indirect pathway projection
neurons (dSPN and iSPN) that are intermingled in all compartments. While such cellular …

[HTML][HTML] The origin and diversification of the developmental mechanisms that pattern the vertebrate head skeleton

T Square, D Jandzik, M Romášek, R Cerny… - Developmental …, 2017 - Elsevier
The apparent evolvability of the vertebrate head skeleton has allowed a diverse array of
shapes, sizes, and compositions of the head in order to better adapt species to their …