Few environmental factors have a larger influence on animal energetics than temperature, a
fact that makes thermoregulation a very important process for survival. In general …

Torpor during hibernation defines the nadir of mammalian metabolism where whole animal
rates of metabolism are decreased to as low as 2% of basal metabolic rate. This capacity to …

Naked mole-rats are among the most hypoxia-tolerant mammals. During hypoxia, their body
temperature (T b) decreases via unknown mechanisms to conserve energy. In small …

Basal metabolic rate (BMR, mL O2 h− 1) is a useful measurement only if standard conditions
are realised. We present an analysis of the relationship between mammalian body mass (M …

▪ Abstract Hypoxia elicits an array of compensatory responses in animals ranging from
protozoa to mammals. Central among these responses is anapyrexia, the regulated …

Mammalian hibernation is an amazing strategy for winter survival. Animals sink into a deep
torpor where metabolic rate is< 5% of normal, body temperature falls to 0–5¡ ãC, and …

The malignancy of glioblastoma (GBM), the most aggressive type of human brain tumor,
strongly correlates with the presence of hypoxic areas within the tumor mass. Oxygen levels …

Heterothermic mammals tolerate severe hypoxia, as well as a variety of central nervous
system insults, better than homeothermic mammals. Tolerance to hypoxia may stem from …

In response to varying environmental and physiological challenges, vertebrates have
evolved complex and often overlapping systems. These systems detect changes in …

The hypoxic metabolic response of mammals involves a reversible metabolic suppression,
possibly brought about by a reduction in the body temperature set-point. In the present study …