Recent developments in synthetic α-glucosidase inhibitors: A comprehensive review with structural and molecular insight
Diabetes mellitus is the prominent metabolic disorder affecting 422 million people around
the globe and cause severe associated problems like kidney disorders, heart and nervous …
the globe and cause severe associated problems like kidney disorders, heart and nervous …
Cyclic tailor-made amino acids in the design of modern pharmaceuticals
J Liu, J Han, K Izawa, T Sato, S White… - European Journal of …, 2020 - Elsevier
Tailor-made AAs are indispensable components of modern medicinal chemistry and are
becoming increasingly prominent in new drugs. In fact, about 30% of small-molecule …
becoming increasingly prominent in new drugs. In fact, about 30% of small-molecule …
Inhibitory effect of polyphenols from the whole green jackfruit flour against α-glucosidase, α-amylase, aldose reductase and glycation at multiple stages and their …
For the first time, α-glucosidase, α-amylase, aldose reductase, and glycation at multiple
stages inhibitory assays were used to explore the antidiabetic potential of whole unripe …
stages inhibitory assays were used to explore the antidiabetic potential of whole unripe …
Synthesis of new bis (dimethylamino) benzophenone hydrazone for diabetic management: In-vitro and in-silico approach
Inhibiting α-glucosidase is a reliable method for reducing blood sugar levels in diabetic
individuals. Bis (dimethylamino) benzophenone derivatives 1–27 were synthesized from bis …
individuals. Bis (dimethylamino) benzophenone derivatives 1–27 were synthesized from bis …
Synthesis and bioactivities evaluation of oleanolic acid oxime ester derivatives as α-glucosidase and α-amylase inhibitors
XY Deng, JJ Ke, YY Zheng, DL Li, K Zhang… - Journal of Enzyme …, 2022 - Taylor & Francis
Different oleanolic acid (OA) oxime ester derivatives (3a-3t) were designed and synthesised
to develop inhibitors against α-glucosidase and α-amylase. All the synthesised OA …
to develop inhibitors against α-glucosidase and α-amylase. All the synthesised OA …
Design, synthesis, in vitro, and in silico enzymatic evaluations of thieno [2, 3-b] quinoline-hydrazones as novel inhibitors for α-glucosidase
M Noori, M Rastak, M Halimi, MK Ghomi… - Bioorganic …, 2022 - Elsevier
In the development of novel anti-α-glucosidase agents, we synthesized novel thieno [2, 3-b]
quinoline-hydrazones 9a-n by facile and efficient conventional chemical reactions. These …
quinoline-hydrazones 9a-n by facile and efficient conventional chemical reactions. These …
Selenourea and thiourea derivatives of chiral and achiral enetetramines: Synthesis, characterization and enzyme inhibitory properties
A series of chiral and achiral cyclic seleno-and thiourea compounds bearing benzyl groups
on N-atoms were prepared from enetetramines and appropriate Group VI elements in good …
on N-atoms were prepared from enetetramines and appropriate Group VI elements in good …
Design and synthesis of novel pyrazole-phenyl semicarbazone derivatives as potential α-glucosidase inhibitor: Kinetics and molecular dynamics simulation study
A series of novel pyrazole-phenyl semicarbazone derivatives were designed, synthesized,
and screened for in vitro α-glucosidase inhibitory activity. Given the importance of hydrogen …
and screened for in vitro α-glucosidase inhibitory activity. Given the importance of hydrogen …
Design and synthesis of novel quinazolinone-pyrazole derivatives as potential α-glucosidase inhibitors: Structure-activity relationship, molecular modeling and kinetic …
In this study, a new series of quinazolinone-pyrazole hybrids were designed, synthesized
and screened for their α-glucosidase inhibitory activity. The results of the in vitro screening …
and screened for their α-glucosidase inhibitory activity. The results of the in vitro screening …
Multiprotein inhibitory effect of dietary polyphenol rutin from whole green jackfruit flour targeting different stages of diabetes mellitus: defining a bio-computational …
The anti-diabetic potential of whole unripe jackfruit (peel with pulp, flake, and seed) was
investigated using inhibitory assays for α-glucosidase, α-amylase, aldose reductase, and …
investigated using inhibitory assays for α-glucosidase, α-amylase, aldose reductase, and …