Drug repurposing to overcome microbial resistance
J Jampilek - Drug Discovery Today, 2022 - Elsevier
Infections are a growing global threat, and the number of resistant species of microbial
pathogens is alarming. However, the rapid development of cross-resistant or multidrug …
pathogens is alarming. However, the rapid development of cross-resistant or multidrug …
[HTML][HTML] Antimicrobial activity of non-steroidal anti-inflammatory drugs on biofilm: Current evidence and potential for drug repurposing
RC Paes Leme, RB da Silva - Frontiers in microbiology, 2021 - frontiersin.org
It has been demonstrated that some non-steroidal anti-inflammatory drugs (NSAIDs), like
acetylsalicylic acid, diclofenac, and ibuprofen, have anti-biofilm activity in concentrations …
acetylsalicylic acid, diclofenac, and ibuprofen, have anti-biofilm activity in concentrations …
Repositioning of non-antibiotic drugs as an alternative to microbial resistance: a systematic review
VS Foletto, TF da Rosa, MB Serafin, A Bottega… - International Journal of …, 2021 - Elsevier
The global spread of microbial resistance coupled with high costs and slow pace in the
discovery of a new antibiotic have made drug repositioning an attractive and promising …
discovery of a new antibiotic have made drug repositioning an attractive and promising …
[HTML][HTML] Using Caenorhabditis elegans to Model Therapeutic Interventions of Neurodegenerative Diseases Targeting Microbe-Host Interactions
Emerging evidence from both clinical studies and animal models indicates the importance of
the interaction between the gut microbiome and the brain in the pathogenesis of …
the interaction between the gut microbiome and the brain in the pathogenesis of …
[HTML][HTML] Aspirin and infection: A narrative review
Acetylsalicylic acid (ASA) is one of the most commonly used drugs in the world. It derives
from the extract of white willow bark, whose therapeutic potential was known in Egypt since …
from the extract of white willow bark, whose therapeutic potential was known in Egypt since …
Biofilm Formation by Staphylococcus epidermidis and Its Inhibition Using Carvacrol, 2-Aminobenzemidazole, and 3-Indole Acetonitrile
Biofilm-associated bacterial infections are problematic for physicians due to high
antimicrobial resistance in biofilm-forming bacteria. Staphylococcus species, particularly …
antimicrobial resistance in biofilm-forming bacteria. Staphylococcus species, particularly …
Antibacterial and physical characteristics of silver-loaded hydroxyapatite/alginate composites
LF Sukhodub, AD Pogrebnjak… - Functional …, 2021 - iopscience.iop.org
The influence of silver ions on the antibacterial properties and morphology of hydroxyapatite-
silver (HA-Ag) and hydroxyapatite-alginate-silver (HA-Alg-Ag) nanocomposites was studied …
silver (HA-Ag) and hydroxyapatite-alginate-silver (HA-Alg-Ag) nanocomposites was studied …
Antibiofilm Mechanisms of the Helical G3 Peptide against Staphylococcus epidermidis
C Chen, Q Gu, Y Ge, J Tian, Y Zhang, T Wang… - Langmuir, 2024 - ACS Publications
Antibacterial peptides (ABPs) have been recognized as promising alternatives to
conventional antibiotics due to their broad antibacterial spectrum, high antibacterial activity …
conventional antibiotics due to their broad antibacterial spectrum, high antibacterial activity …
[HTML][HTML] The Promising Effect of Ascorbic Acid and Paracetamol as Anti-Biofilm and Anti-Virulence Agents against Resistant Escherichia coli
Escherichia coli is a major cause of serious infections, with antibiotic resistance rendering
many treatments ineffective. Hence, novel strategies to combat this pathogen are needed …
many treatments ineffective. Hence, novel strategies to combat this pathogen are needed …
[HTML][HTML] Repurposing Synthetic Acetaminophen Derivatives Containing a Benzothiazole Scaffold as an Alternative Therapy for Infectious Diarrhea Caused by Drug …
B Pone Kamdem, BR Pinlap… - Future …, 2024 - mdpi.com
Diarrhea remains one of the leading causes of mortality worldwide, especially among
children. Accumulated evidence has shown that Shigella species are the most prevalent …
children. Accumulated evidence has shown that Shigella species are the most prevalent …