The origin of interspersed repeats in the human genome
AFA Smit - Current opinion in genetics & development, 1996 - Elsevier
Over a third of the human genome consists of interspersed repetitive sequences which are
primarily degenerate copies of transposable elements. In the past year, the identities of …
primarily degenerate copies of transposable elements. In the past year, the identities of …
HIV-1 infection activates endogenous retroviral promoters regulating antiviral gene expression
S Srinivasachar Badarinarayan… - Nucleic Acids …, 2020 - academic.oup.com
Although endogenous retroviruses (ERVs) are known to harbor cis-regulatory elements,
their role in modulating cellular immune responses remains poorly understood. Using an …
their role in modulating cellular immune responses remains poorly understood. Using an …
Human endogenous retroviruses in the primate lineage and their influence on host genomes
J Mayer, E Meese - Cytogenetic and Genome Research, 2005 - karger.com
Primates emerged about 60 million years ago. Since that time various primate-targeting
retroviruses have integrated in the germ line of primate species, and some drifted to fixation …
retroviruses have integrated in the germ line of primate species, and some drifted to fixation …
All three variable regions of the TRIM5α B30. 2 domain can contribute to the specificity of retrovirus restriction
Recent studies have revealed the contribution of TRIM5α to retrovirus restriction in cells from
a variety of primate species. TRIM5α consists of a tripartite motif (the RBCC domain) …
a variety of primate species. TRIM5α consists of a tripartite motif (the RBCC domain) …
[HTML][HTML] Comprehensive identification of genes driven by ERV9-LTRs reveals TNFRSF10B as a re-activatable mediator of testicular cancer cell death
U Beyer, SK Krönung, A Leha, L Walter… - Cell Death & …, 2016 - nature.com
The long terminal repeat (LTR) of human endogenous retrovirus type 9 (ERV9) acts as a
germline-specific promoter that induces the expression of a proapoptotic isoform of the …
germline-specific promoter that induces the expression of a proapoptotic isoform of the …
Human IRGM gene “to be or not to be”
C Bekpen, RJ Xavier, EE Eichler - Seminars in immunopathology, 2010 - Springer
The immunity-related GTPases (IRG proteins) are one of the strongest early resistance
systems against intracellular pathogens. The IRG gene family contains 21 copies arranged …
systems against intracellular pathogens. The IRG gene family contains 21 copies arranged …
The solitary long terminal repeats of ERV-9 endogenous retrovirus are conserved during primate evolution and possess enhancer activities in embryonic and …
J Ling, W Pi, R Bollag, S Zeng, M Keskintepe… - Journal of …, 2002 - Am Soc Microbiol
The solitary long terminal repeats (LTRs) of ERV-9 endogenous retrovirus contain the U3, R,
and U5 regions but no internal viral genes. They are middle repetitive DNAs present at …
and U5 regions but no internal viral genes. They are middle repetitive DNAs present at …
Human gene mutation in pathology and evolution
DN Cooper - Journal of inherited metabolic disease, 2002 - Wiley Online Library
Mutations in human gene pathology and evolution represent two sides of the same coin in
that the same mechanisms that have frequently been implicated in disease‐associated …
that the same mechanisms that have frequently been implicated in disease‐associated …
A long terminal repeat of the human endogenous retrovirus ERV-9 is located in the 5′ boundary area of the human β-globin locus control region
Q Long, C Bengra, C Li, F Kutlar, D Tuan - Genomics, 1998 - Elsevier
Transcription of the human β-like globin genes in erythroid cells is regulated by the far-
upstream locus control region (LCR). In an attempt to define the 5′ border of the LCR, we …
upstream locus control region (LCR). In an attempt to define the 5′ border of the LCR, we …
The LTR enhancer of ERV-9 human endogenous retrovirus is active in oocytes and progenitor cells in transgenic zebrafish and humans
W Pi, Z Yang, J Wang, L Ruan, X Yu… - Proceedings of the …, 2004 - National Acad Sciences
The solitary LTRs of ERV-9 human endogenous retrovirus are middle repetitive DNAs
associated with 3,000–4,000 human gene loci including the β-globin gene locus where the …
associated with 3,000–4,000 human gene loci including the β-globin gene locus where the …