The human history has witnessed the rapid development of technologies such as high-
throughput sequencing and mass spectrometry that led to the concept of 'omics' and …

The accumulation of protein inclusions is linked to many neurodegenerative diseases that
typically develop in older individuals, due to a combination of genetic and environmental …

Abstract The" Protein Abundances Across Organisms" database (PaxDb) is an integrative
metaresource dedicated to protein abundance levels, in tissue-specific or whole-organism …

Co-fractionation/mass spectrometry (CF/MS) enables the mapping of endogenous
macromolecular networks on a proteome scale, but current methods are experimentally …

Biological research has undergone tremendous changes over the past three decades.
Research used to almost exclusively focus on a single aspect of a single molecule per …

Most proteins are organized in macromolecular assemblies, which represent key functional
units regulating and catalyzing most cellular processes. Affinity purification of the protein of …

Co-fractionation mass spectrometry (CF-MS) has emerged as a powerful technique for
interactome mapping. However, there is little consensus on optimal strategies for the design …

Despite the availability of methods for analyzing protein complexes, systematic analysis of
complexes under multiple conditions remains challenging. Approaches based on …

Tinnitus, a phantom perception of sound in the absence of any external sound source, is a
prevalent health condition often accompanied by psychiatric comorbidities. Recent genome …

The synthesis and trafficking of iron-sulfur (Fe-S) clusters in both prokaryotes and
eukaryotes requires coordination within an expanding network of proteins that function in the …