Native mass spectrometry: recent progress and remaining challenges

KR Karch, DT Snyder, SR Harvey… - Annual review of …, 2022 - annualreviews.org
Native mass spectrometry (nMS) has emerged as an important tool in studying the structure
and function of macromolecules and their complexes in the gas phase. In this review, we …

Native mass spectrometry of membrane proteins

JE Keener, G Zhang, MT Marty - Analytical chemistry, 2020 - ACS Publications
Biological membranes formed of amphipathic lipid bilayers provide chemical barriers to
separate cells from their external environments and define subcellular compartments …

Approaches to heterogeneity in native mass spectrometry

AD Rolland, JS Prell - Chemical reviews, 2021 - ACS Publications
Native mass spectrometry (MS) is aimed at preserving and determining the native structure,
composition, and stoichiometry of biomolecules and their complexes from solution after they …

Variable-temperature electrospray ionization for temperature-dependent folding/refolding reactions of proteins and ligand binding

JW McCabe, M Shirzadeh, TE Walker, CW Lin… - Analytical …, 2021 - ACS Publications
Stabilities and structure (s) of proteins are directly coupled to their local environment or
Gibbs free energy landscape as defined by solvent, temperature, pressure, and …

Fourier transform-ion mobility-orbitrap mass spectrometer: a next-generation instrument for native mass spectrometry

ML Poltash, JW McCabe, M Shirzadeh… - Analytical …, 2018 - ACS Publications
A new instrument configuration for native ion mobility-mass spectrometry (IM-MS) is
described. Macromolecule ions are generated by using a static ESI source coupled to an RF …

First-principles collision cross section measurements of large proteins and protein complexes

JW McCabe, CS Mallis, KI Kocurek… - Analytical …, 2020 - ACS Publications
Rotationally averaged collision cross section (CCS) values for a series of proteins and
protein complexes ranging in size from 8.6 to 810 kDa are reported. The CCSs were …

[HTML][HTML] Interpol review of detection and characterization of explosives and explosives residues 2016-2019

DJ Klapec, G Czarnopys, J Pannuto - Forensic science international …, 2020 - Elsevier
This review paper covers the forensic-relevant literature for the analysis and detection of
explosives and explosives residues from 2016-2019 as a part of the 19 th Interpol …

Selective regulation of human TRAAK channels by biologically active phospholipids

S Schrecke, Y Zhu, JW McCabe, M Bartz… - Nature chemical …, 2021 - nature.com
TRAAK is an ion channel from the two-pore domain potassium (K2P) channel family with
roles in maintaining the resting membrane potential and fast action potential conduction …

Cardiolipin regulates the activity of the mitochondrial ABC transporter ABCB10

T Zhang, J Lyu, Y Zhu, A Laganowsky - Biochemistry, 2023 - ACS Publications
The ATP-binding cassette (ABC) transporter ABCB10 resides in the inner membrane of
mitochondria and is implicated in erythropoiesis. Mitochondria from different cell types share …

Implementing Digital-Waveform Technology for Extended m/z Range Operation on a Native Dual-Quadrupole FT-IM-Orbitrap Mass Spectrometer

JW McCabe, BJ Jones, TE Walker… - Journal of the …, 2021 - ACS Publications
Here, we describe a digital-waveform dual-quadrupole mass spectrometer that enhances
the performance of our drift tube FT-IMS high-resolution Orbitrap mass spectrometer (MS) …