Patients with Alzheimer's disease (AD) present with both extracellular amyloid-β (Aβ)
plaques and intracellular tau-containing neurofibrillary tangles in the brain. For many years …

Extracellular neuritic plaques composed of amyloid‑β (Aβ) protein and intracellular
neurofibrillary tangles containing phosphorylated tau protein are the two hallmark proteins of …

Proteomics can shed light on the dynamic and multifaceted alterations in neurodegenerative
disorders like Alzheimer's disease (AD). Combining radioligands measuring β-amyloid (Aβ) …

Alzheimer's disease (AD) is a progressive neurodegenerative disorder leading to loss of
cognitive abilities and ultimately, death. With no cure available, limited treatments mostly …

The coexistence of amyloid-β (Aβ) plaques and tau neurofibrillary tangles in the neocortex is
linked to neural system failure and cognitive decline in Alzheimer's disease. However, the …

People with epilepsy—in particular, late-onset epilepsy of unknown aetiology—have an
elevated risk of dementia, and seizures have been detected in the early stages of Alzheimer …

Biophysical modeling of neuronal networks helps to integrate and interpret rapidly growing
and disparate experimental datasets at multiple scales. The NetPyNE tool (www. netpyne …

Alzheimer's disease (AD) is the most frequent neurodegenerative disorder that commonly
causes dementia in the elderly. Recent evidence indicates that network abnormalities …

Disinhibition during early stages of Alzheimer's disease is postulated to cause network
dysfunction and hyperexcitability leading to cognitive deficits. However, the underlying …

Neural synchrony is intricately balanced in the normal resting brain but becomes altered in
Alzheimer's disease (AD). To determine the neurophysiological manifestations associated …